Kazusamycin A

• 产品号: K1764
• CAS号: 92090-94-3
• 分子式: C33H48O7
• 分子量: 556.73002
• 纯 度: ≥95% (HPLC)

产品别名

• 标题: Kazusamycin A
• IUPAC标准名: (2E,10E,12E,16E,18E)-17-ethyl-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15-pentamethyl-19-(3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid
• IUPAC传统名: (2E,10E,12E,16E,18E)-17-ethyl-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15-pentamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid

产品登记号

• MDL号: MFCD03265635
• CAS号: 92090-94-3

产品性质

• 生物来源: from Streptomyces sp.
• 纯度: ≥95% (HPLC)
• 运输包装: dry ice
• 外观: aqueous methanol solution
• 闪点: 15 °C
• 闪点: 59 °F
• 溶解度: methanol: water: soluble7:3
• 溶解度: DMSO: soluble
• 溶解度: H2O: insoluble
• 溶解度: chloroform: soluble
• 溶解度: ethanol: soluble
• 溶解度: hexane: insoluble
• 溶解度: methanol: soluble
• GHS警示词: Danger
• GHS危险声明: H225-H301-H311-H331-H370
• 欧盟危险性物质标志: 易燃性(Flammable) (F)
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• GHS警示性声明: P210-P260-P280-P301 + P310-P311
• RID/ADR: UN 1230 3/PG 2
• 危险公开号: 11-23/24/25-39/23/24/25
• 安全公开号: 16-36/37-45
• 保存温度: -20°C
• 联合国危险货物等级: 3
• 联合国危险货物编号: 1230
• 联合国危险货物包装类别(PG): 2
• 德国WGK号: 1

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Kazusamycin A, an unsaturated branched chain fatty acid with a terminal lactone ring, is a hydroxy analog of Leptomycin B. It has significant in vitro cytotoxic activity against various human and mouse tumor lines encompassing a wide range of tissue types. Kazusamycin A exhibits in vivo antitumor activity against experimental murine tumors. It inhibits nuclear export and Rev translocation, a regulatory gene product in the HIV genome, at nanomolar concentrations.
Physical form
70% methanol solution.