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G 418 二硫酸盐_分子结构_CAS_108321-42-2)
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G 418 二硫酸盐

产品号 G1279 公司名称 Sigma Aldrich
CAS号 108321-42-2 公司网站 http://www.sigmaaldrich.com
分子式 C20H44N4O18S2 电 话 1-800-521-8956
分子量 692.70936 传 真
纯 度 电子邮件
保 存 Chembase数据库ID: 131635

产品价格信息

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产品别名

标题
G 418 disulfate salt
IUPAC标准名
(2R,3S,4R,5R,6S)-5-amino-6-{[(1R,2S,3S,4R,6S)-4,6-diamino-3-{[(2S,3S,4S,5S)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-2-(1-hydroxyethyl)oxane-3,4-diol; bis(sulfuric acid)
IUPAC传统名
(2R,3S,4R,5R,6S)-5-amino-6-{[(1R,2S,3S,4R,6S)-4,6-diamino-3-{[(2S,3S,4S,5S)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-2-(1-hydroxyethyl)oxane-3,4-diol; bis(sulfuric acid)
别名
抗生物質G418

产品登记号

PubChem SID 24895058
CAS号 108321-42-2
MDL号 MFCD00058314

产品性质

适用性 plant cell culture tested
个人保护装置 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
保存温度 2-8°C
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
G 418 blocks polypeptide synthesis by interfering with ribosomal function and inhibiting protein elongation.
Mode of Action: Blocks polypeptide synthesis by inhibiting protein elongation. For use in the selection and maintenance of eukaryotic cells stably transfected with neomycin resistance genes.
Other Notes
Aminoglycoside antibiotic similar in structure to gentamicin, neomycin and kanamycin.
Application
G 418 is a Micromonospora-produced aminoglycoside antibiotic with activity against protozoa and helminths1. G 418 disulfate salt is used for selection and maintenance of prokaryotic and eukaryotic cells transfected with a iNOS promoter construct and neomycin resistance gene2.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

参考文献