反式-脱氢雄甾酮

• 产品号: D4000
• CAS号: 53-43-0
• 分子式: C19H28O2
• 分子量: 288.42442
• 纯 度: ≥99%

产品别名

• 标题: trans-Dehydroandrosterone
• IUPAC标准名: (1S,2R,5S,10R,11S,15S)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadec-7-en-14-one
• IUPAC传统名: dehydroepiandrosterone
• 别名: 3β-羟基-5-雄烯-17-酮; 雄素-5-烯-3β-醇-17-酮; 普拉睾酮; DHEA; 去氢表雄酮; 脱氢异雄酮

产品登记号

• Beilstein号: 2058110
• PubChem SID: 24278369
• CAS号: 53-43-0
• EC号: 200-175-5
• MDL号: MFCD00003613

产品性质

• 纯度: ≥99%
• 相关基因信息: human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), SERPINA6(866)rat ... Ar(24208)
• 熔点: 149-151 °C(lit.)
• 毒品管制信息: Home Office Schedule 4.2regulated under CDSA - not available from Sigma-Aldrich Canada
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• RTECS编号: BV8396000
• 安全公开号: 26-36
• 德国WGK号: 2

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Dehydroandrosterone (DHEA) is a negative modulator of GABAA receptors. It is a steroid secreted by the adrenal gland with both estrogenic and androgenic properties. DHEAs conversion to 5-androstenediol, a potent estrogen, enhances the growth and survival of estrogen-sensitive breast tumors.
Negative modulator of GABAA receptors. Steroid secreted by the adrenal gland with both estrogenic and androgenic properties. Its conversion to 5-androstenediol, a potent estrogen, enhances the growth and survival of estrogen-sensitive breast tumors. At high but physiologically valid concentrations, DHEA inhibits proliferation of chromaffin progenitor cells and induces dopaminergic differentiation.