13-cis-Retinoic acid

• 产品号: R3255
• CAS号: 4759-48-2
• 分子式: C20H28O2
• 分子量: 300.43512
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: 13-cis-Retinoic acid
• IUPAC标准名: (2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
• IUPAC传统名: isotretinoin
• 别名: Isotretinoin

产品登记号

• PubChem SID: 24278676
• CAS号: 4759-48-2
• EC号: 225-296-0
• MDL号: MFCD00079542

产品性质

• 纯度: ≥98% (HPLC)
• 相关基因信息: human ... NOS2(4843), RARA(5914), RARB(5915)
• 熔点: 172-175 °C(lit.)
• GHS警示词: Danger
• GHS危险声明: H315-H319-H335-H360
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P201-P261-P305 + P351 + P338-P308 + P313
• 危险公开号: 61-36/37/38
• RTECS编号: VH6440000
• 安全公开号: 53-26-36/37/39-45
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
13-cis-Retinoic acid (RA) has anti-inflammatory and anti-tumor action. The action of RA is mediated through RAR-β and RAR-α receptors. RA attenuates iNOS expression and activity in cytokine-stimulated murine mesangial cells. It induces mitochondrial membrane permeability transition, observed as swelling and as a decrease in membrane potential, and stimulates the release of cytochrome c implicating mechanisms through the apoptosis pathway. These activities are reversed by EGTA and cyclosporin A. RA also increases MMP-1 protein expression partially via increased transcription.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. R3255.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.