Adrenocorticotropic Hormone Fragment 4-10 human, rat

• 产品号: A0401
• CAS号: 4037-01-8
• 分子式: C44H59N13O10S
• 分子量: 962.08536
• 纯 度: ≥97% (HPLC)

产品别名

• 标题: Adrenocorticotropic Hormone Fragment 4-10 human, rat
• IUPAC标准名: 4-[2-amino-4-(methylsulfanyl)butanamido]-4-({1-[(1-{[4-carbamimidamido-1-({1-[(carboxymethyl)carbamoyl]-2-(1H-indol-3-yl)ethyl}carbamoyl)butyl]carbamoyl}-2-phenylethyl)carbamoyl]-2-(1H-imidazol-5-yl)ethyl}carbamoyl)butanoic acid
• IUPAC传统名: 4-[2-amino-4-(methylsulfanyl)butanamido]-4-{[1-({1-[(4-carbamimidamido-1-{[1-(carboxymethylcarbamoyl)-2-(1H-indol-3-yl)ethyl]carbamoyl}butyl)carbamoyl]-2-phenylethyl}carbamoyl)-2-(3H-imidazol-4-yl)ethyl]carbamoyl}butanoic acid
• 别名: ACTH4-10

产品登记号

• CAS号: 4037-01-8
• PubChem SID: 24890423
• MDL号: MFCD00167482

产品性质

• 纯度: ≥97% (HPLC)
• 相关基因信息: human ... POMC(5443)rat ... Crhr2(64680)
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Amino Acid Sequence
Met-Glu-His-Phe-Arg-Trp-Gly
Other Notes
Core fragment of ACTH, α- and β-MSH, and β-lipotropin
Quality
Lacks adrenocorticotropic activity.
Biochem/physiol Actions
Adrenocorticotropic Hormone Fragment 4-10 (ACTH (4-10)) attenuates ischemia/reperfusion-induced cardiac injury via reduction in infarct size, caspase 3 activity, and apoptosis, and an increase in HO-1 expression. ACTH 4-10 is a melanocortin 4 receptor (MCR-4) agonist. ACTH 4-10 facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval. ACTH 4-10 and semax are analogues.