Homoharringtonine

• 产品号: H0635
• CAS号: 26833-87-4
• 分子式: C29H39NO9
• 分子量: 545.62126

产品别名

• 标题: Homoharringtonine
• IUPAC标准名: (2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.0^2,^6.0^6,^1^0.0^1^5,^1^9]icosa-1(20),4,13,15(19)-tetraen-3-yl 1-methyl (3R)-3-hydroxy-3-(4-hydroxy-4-methylpentyl)butanedioate
• IUPAC传统名: omacetaxine mepesuccinate

产品登记号

• MDL号: MFCD03410264
• PubChem SID: 24895407
• CAS号: 26833-87-4

产品性质

• GHS警示词: Danger
• GHS危险声明: H300-H310-H330
• 欧盟危险性物质标志: 剧毒(Highly toxic) (T+)
• 个人保护装置: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P260-P264-P280-P284-P302 + P350-P310
• RID/ADR: UN 1544 6.1/PG 2
• 危险公开号: 26/27/28
• RTECS编号: FK0260000
• 安全公开号: 36/37/39-45
• 保存温度: 2-8°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 1544
• 联合国危险货物包装类别(PG): 2
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Homoharringtonine is a cytotoxic alkaloid from the evergreen tree, Cephalotaxus hainanensis. Binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation. Blocks progression of leukemic cells from G1 phase into S phase and from G2 phase into M phase.