Daptomycin

• 产品号: Daptomycin
• CAS号: 103060-53-3
• 分子式: C72H101N17O26
• 分子量: 1620.67064

产品别名

• 标题: Daptomycin
• IUPAC标准名: (3S)-3-{[(3S,6S,9R,15S,18R,21S,24S)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-(1-carboxypropan-2-yl)-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]carbamoyl}-3-[(2S)-3-carbamoyl-2-[(2S)-2-decanamido-3-(1H-indol-3-yl)propanamido]propanamido]propanoic acid
• IUPAC传统名: daptomycin
• 商标名: Cubicin

产品登记号

• CAS号: 103060-53-3
• CHEMBL: 508162
• 美国药典/FDA物质标识码: NWQ5N31VKK
• PubChem CID: 16129629
• DrugBank ID: DB00080
• 维基百科标题: Daptomycin
• KEGG ID: D01080
• Chemspider ID: 10482098
• ATC码: J01XX09

产品性质

• 给药途径: Intravenous
• 生物利用度: n/a
• 排泄: Renal (78%; primarily as unchanged drug); Faeces (5.7%)
• 半衰期: 7–11 hours (up to 28 hours in renal impairment)
• 法定药品分级: Rx-only (US)
• 代谢: Renal (speculative)
• 妊娠期药物分类: B (US)
• 蛋白结合率: 90–95%