Sirolimus

• 产品号: Sirolimus
• CAS号: 53123-88-9
• 分子式: C51H79NO13
• 分子量: 914.17186

产品别名

• 标题: Sirolimus
• IUPAC标准名: (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28Z,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0^4,^9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
• IUPAC传统名: (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28Z,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0^4,^9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone

产品登记号

• PubChem CID: 5284616
• CHEMBL: 413
• 美国药典/FDA物质标识码: W36ZG6FT64
• Chemspider ID: 10482078
• KEGG ID: D00753
• CHEBI ID: 9168
• 维基百科标题: Sirolimus
• ATC码: L04AA10
• CAS号: 53123-88-9
• DrugBank ID: DB00877

产品性质

• 给药途径: Oral
• 生物利用度: 20%, less after eating food rich in fat
• 排泄: Mostly faecal
• 半衰期: 57–63 hours
• 法定药品分级: Rx-only (US)
• 欧盟（EMEA）药品许可证: Rapamune
• 美国（FDA）药品许可证: Sirolimus
• 代谢: Hepatic
• 妊娠期药物分类: C (US)
• 妊娠期药物分类: C (Australia)
• 蛋白结合率: 92%