Heroin

• 产品号: Heroin
• CAS号: 561-27-3
• 分子式: C21H23NO5
• 分子量: 369.41102

产品别名

• 标题: Heroin
• IUPAC标准名: (1S,5R,13R,14S,17R)-14-(acetyloxy)-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^1,^1^3.0^5,^1^7.0^7,^1^8]octadeca-7,9,11(18),15-tetraen-10-yl acetate
• IUPAC传统名: (1S,5R,13R,14S,17R)-14-(acetyloxy)-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^1,^1^3.0^5,^1^7.0^7,^1^8]octadeca-7,9,11(18),15-tetraen-10-yl acetate
• 别名: Acetomorphine; Morphine diacetate; Diamorphine; (Dual) Acetylated morphine; Diacetylmorphine

产品登记号

• Chemspider ID: 4575379
• ATC码: N07BC06
• DrugBank ID: DB01452
• CHEBI ID: 27808
• CAS号: 561-27-3
• PubChem CID: 5462328
• 维基百科标题: Heroin
• CHEMBL: 459324
• 美国药典/FDA物质标识码: 8H672SHT8E

产品性质

• 给药途径: Inhalation, Transmucosal, Intravenous, Oral, Intranasal, Rectal, Intramuscular
• 生物利用度: <35% (oral), 44–61% (inhaled)
• 依赖倾向: High
• 排泄: 90% renal as glucuronides, rest biliary
• 半衰期: <10 minutes
• 法定药品分级: S9 (Australia)
• 法定药品分级: Schedule I (Canada)
• 法定药品分级: Class A (UK)
• 法定药品分级: Schedule I (US)
• 代谢: hepatic
• 妊娠期药物分类: Not yet classified, but studies have shown a risk of abnormalities, hepatitis, malnutrition, and many other effects.
• 蛋白结合率: 0% (morphine metabolite 35%)