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Conjugated Estrogens_分子结构_CAS_438-67-5)
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Conjugated Estrogens

产品号 DB00286 公司名称 DrugBank
CAS号 438-67-5 公司网站 http://www.ualberta.ca/
分子式 C18H21NaO5S 电 话 (780) 492-3111
分子量 372.41111 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 171

产品价格信息

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产品别名

标题
Conjugated Estrogens
IUPAC标准名
sodium (1S,10R,11S,15S)-15-methyl-14-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-trien-5-yl sulfate
IUPAC传统名
potassium estrone 3-sulfate(1-)
商标名
Evex
Conestoral
Hyhorin
Par Estro
Premarin
Prempro/Premphase
Prempro
Morestin
Premarin tabs
Premarin Vaginal
别名
Estrone Sulphate
Estrogens
Estrone Sodium Sulfate
Estrone Sulfate Sodium
Estrone Estrone Hydrogen Sulfate
Estrone-sulfate
Estrone Sulfate
Estrone Hydrogen Sulfate
Oestrone Sulphate
Sodium Estrone Sulfate

产品登记号

CAS号 438-67-5
PubChem CID 23667301
PubChem SID 46505680

产品性质

溶解度 0.0036 mg/ml

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description Conjugated estrogens, a mixture of the water-soluble salts of sulfate esters from estrone, equilin, 17 α-dihydroequilin, and other related steroids, may be derived from pregnant equine urine or yam and soy plants. Estrogens are important in the development and maintenance of the female reproductive system and secondary sex characteristics.
Indication For the treatment of moderate to severe vasomotor symptoms associated with the menopause, atrophic vaginitis, osteoporosis, hypoestrogenism due to hypogonadism, castration, primary ovarian failure, breast cancer (for palliation only), and Advanced androgen-dependent carcinoma of the prostate (for palliation only)
Pharmacology Conjugated estrogens, a mixture of the water soluble salts of sulfate esters from estrone, equilin, 17 α-dihydroequilin, and other related steroids, may be derived from pregnant equine urine or yam and soy plants. Estrogens are important in the development and maintenance of the female reproductive system and secondary sex characteristics. They promote growth and development of the vagina, uterus, and fallopian tubes, and enlargement of the breasts. Indirectly, they contribute to the shaping of the skeleton, maintenance of tone and elasticity of urogenital structures, changes in the epiphyses of the long bones that allow for the pubertal growth spurt and its termination, growth of axillary and pubic hair, and pigmentation of the nipples and genitals. Decline of estrogenic activity at the end of the menstrual cycle can bring on menstruation, although the cessation of progesterone secretion is the most important factor in the mature ovulatory cycle. However, in the preovulatory or nonovulatory cycle, estrogen is the primary determinant in the onset of menstruation. Estrogens also affect the release of pituitary gonadotropins. The pharmacologic effects of conjugated estrogens are similar to those of endogenous estrogens.
Toxicity Nausea and vomiting
Affected Organisms
Humans and other mammals
Biotransformation Hepatic
Absorption Well absorbed
Half Life 7.4 hours
Protein Binding 90% bound to plasma proteins
Elimination Estradiol, estrone, and estriol are excreted in the urine, along with glucuronide and sulfate conjugates. Exogenous estrogens are metabolized in the same manner as endogenous estrogens.
External Links
RxList
Drugs.com

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