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L-Ornithine

产品号 DB00129 公司名称 DrugBank
CAS号 70-26-8 公司网站 http://www.ualberta.ca/
分子式 C5H12N2O2 电 话 (780) 492-3111
分子量 132.16098 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 15

产品价格信息

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产品别名

标题
L-Ornithine
IUPAC标准名
(2S)-2,5-diaminopentanoic acid
IUPAC传统名
L-ornithine
商标名
OKG (Nature's Bounty)
别名
2,5-Diaminopentanoate
2,5-Diaminopentanoic acid
2,5-Diaminovaleric acid
Ornithine

产品登记号

CAS号 70-26-8
PubChem CID 6262
PubChem SID 46505239

产品性质

疏水性(logP) -3.3
溶解度 Appreciable

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved; nutraceutical
Description Ornithine is an amino acid produced in the urea cycle by the splitting off of urea from arginine. It is a central part of the urea cycle, which allows for the disposal of excess nitrogen. L-Ornithine is a precursor of citrulline and arginine.
Indication Used for nutritional supplementation, also for treating dietary shortage or imbalance. It has been claimed that ornithine improves athletic performance, has anabolic effects, has wound-healing effects, and is immuno-enhancing.
Pharmacology A non-essential and nonprotein amino acid, ornithine is critical for the production of the body's proteins, enzymes and muscle tissue. Ornithine plays a central role in the urea cycle and is important for the disposal of excess nitrogen (ammonia). Ornithine is the starting point for the synthesis of many polyamines such as putrescine and spermine. Ornithine supplements are claimed to enhance the release of growth hormone and to burn excess body fat. Ornithine is necessary for proper immune function and good liver function.
Toxicity Oral, rat LD50 = 10000 mg/kg
Affected Organisms
Humans and other mammals
Biotransformation Ornithine undergoes extensive metabolism in the liver to L-arginine, polyamines, and proline, and several other metabolites.
Absorption Absorbed from the small intestine via a sodium-dependent active transport process
External Links
Wikipedia
PDRhealth

参考文献