Lymecycline

• 产品号: DB00256
• CAS号: 992-21-2
• 分子式: C29H38N4O10
• 分子量: 602.63282

产品别名

• 标题: Lymecycline
• IUPAC标准名: (2S)-6-[({[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracen-2-yl]formamido}methyl)amino]-2-aminohexanoic acid
• IUPAC传统名: limeciclina
• 商标名: Aureomycin monohydrochloride; Auxeomycin; Aurofac 10; Aureomykoin; B-Aureo; Aureocycline; Aureomycin A-377; Biomitsin; Biomycin A; Biovetin; Flamycin; Orospray; Acronize; Acronize PD; Aureocarmyl; Aureociclina; Aureocina; Aureomicina; Aurofac; Biomitsin hydrochloride; Centraureo; Chrusomykine; Chrysomykine; Clorocipan; Duomycin; Isphamycin; Psittacin hydrochloride; Tetra 5; Tetralysal; Tocopherex; Aureomycin hydrochloride; Aureomycin; Aureociclin; Biomycin hydrochloride; Tetrlysal 300
• 别名: Chlorotetracycline; Chlortetracycline hydrochloride; Chlortetracyclin; 7-Chlorotetracycline; Chlortetracyclinium chloride; Chlortetracycline; Chlorotetracycline hydrochloride; CLTC

产品登记号

• PubChem CID: 24757945
• CAS号: 992-21-2
• PubChem SID: 46505518

产品性质

• 疏水性(logP): 0.3
• 溶解度: Soluble (at all physiological pH values)

产品详细信息

详细说明 (English)

• Drug Groups: approved
• Description: A tetracycline with a 7-chloro substitution. [PubChem]
• Indication: For the treatment of infections and to treat acne. It may also be used to treat urinary tract infections, gum disease, and other bacterial infections such as gonorrhea and chlamydia. Lymecycline is also used commonly as a prophylactic treatment for infection by Bacillus anthracis (anthrax). It is also effective against Yersinia pestis and malaria and is also prescribed for the treatment of Lyme disease.
• Pharmacology: Lymecycline is a tetracycline broad-spectrum antibiotic. It is approximately 5000 times more soluble than tetracycline base and is unique amongst tetracyclines in that it is absorbed by the "active transport" process across the intestinal wall, making use of the same fast and efficient mechanism by which carbohydrates are absorbed. It inhibits cell growth by inhibiting translation.
• Toxicity: Adverse effects include nausea, vomiting, diarrhoea, glossitis, enterocolitis, dysphagia, dermatitis, hypersensitivity reactions, proctitis, and vaginitis.
• Affected Organisms: Enteric bacteria and other eubacteria
• Absorption: Absorption is fast and efficient. Bioavailability is 100% following oral administration.
• References: [Link] ; Meynadier J, Alirezai M: Systemic antibiotics for acne. Dermatology. 1998;196(1):135-9. [Pubmed]
• External Links: Wikipedia

参考文献

• Link
• Meynadier J, Alirezai M: Systemic antibiotics for acne. Dermatology. 1998;196(1):135-9. Pubmed