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Pivmecillinam

产品号 DB01605 公司名称 DrugBank
CAS号 32886-97-8 公司网站 http://www.ualberta.ca/
分子式 C21H33N3O5S 电 话 (780) 492-3111
分子量 439.56882 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 1382

产品价格信息

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产品别名

标题
Pivmecillinam
IUPAC标准名
[(5R,6R)-6-[(E)-(azepan-1-ylmethylidene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carbonyloxy]methyl 2,2-dimethylpropanoate
IUPAC传统名
[(5R,6R)-6-[(E)-(azepan-1-ylmethylidene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carbonyloxy]methyl 2,2-dimethylpropanoate
商标名
Selexid
Coactabs
别名
Pivmecillinamum [inn-latin]
Pivmecilinamo [inn-spanish]
Amdinocillin pivoxil

产品登记号

CAS号 32886-97-8

产品性质

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description Pivmecillinam is a mecillinam prodrug, a pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. It is active against gram-negative organisms and used as for amdinocillin. [PubChem]
Indication Used to treat infections due to mecillinam-sensitive organisms such as urinary tract infections, salmonellosis and typhoid fever.
Pharmacology Pivmecillinam is a pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. It is active against gram-negative organisms and used as for amdinocillin.
Affected Organisms
Enteric bacteria and other eubacteria
Absorption Well absorbed following oral administration.
References
Sjovall J, Huitfeldt B, Magni L, Nord CE: Effect of beta-lactam prodrugs on human intestinal microflora. Scand J Infect Dis Suppl. 1986;49:73-84. [Pubmed]
Graninger W: Pivmecillinam--therapy of choice for lower urinary tract infection. Int J Antimicrob Agents. 2003 Oct;22 Suppl 2:73-8. [Pubmed]
Pivmecillinam (selexid). Drug Ther Bull. 1978 Dec 22;16(26):103-4. [Pubmed]

参考文献

  • Graninger W: Pivmecillinam--therapy of choice for lower urinary tract infection. Int J Antimicrob Agents. 2003 Oct;22 Suppl 2:73-8. Pubmed
  • Sjovall J, Huitfeldt B, Magni L, Nord CE: Effect of beta-lactam prodrugs on human intestinal microflora. Scand J Infect Dis Suppl. 1986;49:73-84. Pubmed
  • Pivmecillinam (selexid). Drug Ther Bull. 1978 Dec 22;16(26):103-4. Pubmed