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Probucol

产品号 DB01599 公司名称 DrugBank
CAS号 23288-49-5 公司网站 http://www.ualberta.ca/
分子式 C31H48O2S2 电 话 (780) 492-3111
分子量 516.84162 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 1376

产品价格信息

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产品别名

标题
Probucol
IUPAC标准名
2,6-di-tert-butyl-4-({2-[(3,5-di-tert-butyl-4-hydroxyphenyl)sulfanyl]propan-2-yl}sulfanyl)phenol
IUPAC传统名
probucol
商标名
Bisbid
Lorelco
Biphenabid
Lesterol
Lursell
Lurselle
Panavir
Sinlestal
Bisphenabid
别名
Acetone, bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole
4,4'- (Isopropylidenedithio)bis(2, 6-di-tert-butylphenol)
4,4'-(Isopropylidenedithio)bis[2, 6-di-tert-butylphenol]
4,4'-(Isopropylidenedithio)bis(2, 6-di-tert-butylphenol)
4,4'-(Isopropylidenedithio)bis(2,6-di-tert-butylphenol)
Acetone bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole
Acetone, bis (3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole
Probucolum [inn-latin]

产品登记号

PubChem CID 4912
CAS号 23288-49-5
PubChem SID 46508876

产品性质

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
Indication Used to lower LDL and HDL cholesterol.
Pharmacology Probucol lowers the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism. Additionally, probucol may inhibit cholesterol synthesis and delay cholesterol absorption. Probucol is a powerful antioxidant drug normally used to prevent vascular disease caused by the free radicals in the body.
Affected Organisms
Humans and other mammals
Absorption Absorption from the gastrointestinal tract is limited and variable (about 7%).
Half Life Ranges from 12 hours to more than 500 hours, the longest half-life probably being in adipose tissue.
External Links
Wikipedia
Drugs.com

参考文献