Clotiazepam

• 产品号: DB01559
• CAS号: 33671-46-4
• 分子式: C16H15ClN2OS
• 分子量: 318.8211

产品别名

• 标题: Clotiazepam
• IUPAC标准名: 5-(2-chlorophenyl)-7-ethyl-1-methyl-1H,2H,3H-thieno[2,3-e][1,4]diazepin-2-one
• IUPAC传统名: 5-(2-chlorophenyl)-7-ethyl-1-methyl-3H-thieno[2,3-e][1,4]diazepin-2-one
• 商标名: Distensan; Clozan; Rizen; Tienor; Rize; Trecalmo; Veratran
• 别名: Clotiazepamum [inn-latin]

产品登记号

• PubChem SID: 46508776
• CAS号: 33671-46-4
• PubChem CID: 2811

产品性质

• 疏水性(logP): 3.18 [MARUYAMA,T ET AL. (1992)]

产品详细信息

详细说明 (English)

• Drug Groups: illicit; approved
• Description: Clotiazepam is a benzodiazepine derivative, not approved for sale in the U.S. or Canada, but has been approved in the U.K. It is a schedule IV drug in Canada.
• Indication: For the treatment of anxiety disorders.
• Pharmacology: Clotiazepam is a benzodiazepine derivative possessing anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Stage 2 NREM sleep is significantly increased by clotiazepam.
• Affected Organisms: Humans and other mammals
• Biotransformation: Hepatic.
• Half Life: 4 hours
• Protein Binding: 99% bound to plasma proteins.
• References: Nakazawa Y, Kotorii M, Oshima M, Horikawa S, Tachibana H: Effects of thienodiazepine derivatives on human sleep as compared to those of benzodiazepine derivatives. Psychopharmacologia. 1975 Oct 31;44(2):165-71. [Pubmed]
• External Links: Wikipedia

参考文献

• Nakazawa Y, Kotorii M, Oshima M, Horikawa S, Tachibana H: Effects of thienodiazepine derivatives on human sleep as compared to those of benzodiazepine derivatives. Psychopharmacologia. 1975 Oct 31;44(2):165-71. Pubmed