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Dapsone

产品号 DB00250 公司名称 DrugBank
CAS号 80-08-0 公司网站 http://www.ualberta.ca/
分子式 C12H12N2O2S 电 话 (780) 492-3111
分子量 248.30088 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 135

产品价格信息

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产品别名

标题
Dapsone
IUPAC标准名
4-(4-aminobenzenesulfonyl)aniline
IUPAC传统名
4-(4-aminobenzenesulfonyl)aniline
商标名
Avlosulfon
Avlosulfone
Sulfone Ucb
Dimitone
Sulfadione
Tarimyl
Croysulphone
Diphone
Dubronax
Dumitone
Normet
Novophone
Sulfon-Mere
Sulfona
Sulphon-Mere
Araldite Ht
Avlosulphone
Croysulfone
Eporal
ICI
Recolip
Sulfanona-Mae
Sulfona-Mae
Sumicure S
Udolac
别名
P,P-Sulphonylbisbenzenamine
Diaphenylsulfone
DADPS
P, P'-Sulfonyldianiline
P,P-Sulfonylbisbenzamine
P,P'-Diaminodiphenyl Sulfone
N, N'-Diphenyl Sulfondiamide
Sulphadione
Acedapsone
Diamino-diphenyl sulphone
DSS
P-Aminophenyl Sulfone
P,P-Sulphonyldianiline
P,P-Sulfonylbisbenzenamine
P,P-Diaminodiphenyl Sulphone
Sulfonyldianiline
Sulphonyldianiline
Diphenasone
Diaphenylsulphone
Diaminodiphenyl Sulfone
Diaminodifenilsulfona
Dds, Pharmaceutical
Dds, Diaphenylsulfone
DDS
Dapson
dapsone
P,P-Sulphonylbisbenzamine
Metabolite C
Diaphenylsulphon
Diaphenylsulfon
Dapsonum

产品登记号

PubChem SID 46505300
PubChem CID 2955
CAS号 80-08-0

产品性质

疏水性(logP) 0.4
溶解度 380 mg/L

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved; investigational
Description A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
Indication For the treatment and management of leprosy and dermatitis herpetiformis.
Pharmacology Dapsone is a sulfone with anti-inflammatory immunosuppressive properties as well as antibacterial and antibiotic properties. Dapsone is the principal drug in a multidrug regimen recommended by the World Health Organization for the treatment of leprosy. As an anti-infective agent, it is also used for treating malaria and, recently, for Pneumocystic carinii pneumonia in AIDS patients. Dapsone is absorbed rapidly and nearly completely from the gastrointestinal tract. Dapsone is distributed throughout total body water and is present in all tissues. However, it tends to be retained in skin and muscle and especially in the liver and kidney: traces of the drug are present in these organs up to 3 weeks after therapy cessation.
Toxicity Overdosage might be expected to produce nasal congestion, syncope, or hallucinations. Measures to support blood pressure should be taken if necessary.
Affected Organisms
Mycobacteria
Biotransformation Hepatic, mostly CYP2E1-mediated.
Absorption Bioavailability is 70 to 80% following oral administration.
Half Life 28 hours (range 10-50 hours)
Protein Binding 70 to 90%
Elimination Renal
External Links
Wikipedia
RxList
Drugs.com

参考文献