Chlorphentermine

• 产品号: DB01556
• CAS号: 461-78-9
• 分子式: C10H14ClN
• 分子量: 183.67786

产品别名

• 标题: Chlorphentermine
• IUPAC标准名: 1-(4-chlorophenyl)-2-methylpropan-2-amine
• IUPAC传统名: chlorphentermine
• 商标名: Effox; Apsedon; Clomina; Lucofene; Nilgana; Pre-sate; Teramine; Desopimon; Lucofen; Dezopimon
• 别名: 1-(p-Chlorophenyl)-2-methyl-2-aminopropane hydrochloride; alpha,alpha-dimethyl-p-chlorophenethylamine; Chlorphentermine hydrochloride; 1-(p-Chlorophenyl)-2-methyl-2-aminopropane; 4-Chloro-alpha,alpha-dimethylphenethylamine; Chlorpentermine; Chlorphenteramine; P-chloro-alpha,alpha-dimethylphenethylamine; P-chlorphentermine hydrochloride; 1-(4-Chlorophenyl)-2-methyl-2-propanamine; 4-Chloro-alpha,alpha-dimethylbenzeneethanamine; Beta-(p-chlorophenyl)-alpha,alpha-dimethylethylamine; Chlorophentermine; Chlorophentermine hydrochloride; Chlorphenterminum [inn-latin]; Chlorphenterminum hydrochloride; Clorfentermina [inn-spanish]

产品登记号

• PubChem CID: 10007
• CAS号: 461-78-9
• PubChem SID: 46505599

产品性质

• 疏水性(logP): 2.60 [HANSCH,C ET AL. (1995)]

产品详细信息

详细说明 (English)

• Drug Groups: illicit; experimental; withdrawn
• Description: A sympathomimetic agent that was formerly used as an anorectic. It has properties similar to those of dextroamphetamine. It has been implicated in lipid storage disorders and pulmonary hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1223)
• Indication: Used as an appetite suppressant.
• Pharmacology: Chlorphentermine is a relatively weak stimulant with little abuse potential. It is no longer used due mainly to safety concerns, as it has a serotonergic effects profile similar to other withdrawn appetite suppressants such as fenfluramine and aminorex which were found to cause pulmonary hypertension and cardiac fibrosis following prolonged use.
• Absorption: Well absorbed following oral administration.
• Half Life: 40 hours
• References: GYLYS JA, HART JJ, WARREN MR: Chlorphentermine, a new anorectic agent. J Pharmacol Exp Ther. 1962 Sep;137:365-73. [Pubmed]
• External Links: Wikipedia

参考文献

• GYLYS JA, HART JJ, WARREN MR: Chlorphentermine, a new anorectic agent. J Pharmacol Exp Ther. 1962 Sep;137:365-73. Pubmed