Biotin-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-Fluoromethylketone

• 产品号: 03FK019
• 分子式: C38H60FN7O13S
• 分子量: 873.9855032

产品别名

• 标题: Biotin-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-Fluoromethylketone
• IUPAC标准名: methyl (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-(6-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanamido}hexanamido)-4-methoxy-4-oxobutanamido]-5-methoxy-5-oxopentanamido]-3-methylbutanamido]-5-fluoro-4-oxopentanoate
• IUPAC传统名: methyl (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-(6-{5-[(3aS,4S,6aR)-2-oxo-hexahydrothieno[3,4-d]imidazolidin-4-yl]pentanamido}hexanamido)-4-methoxy-4-oxobutanamido]-5-methoxy-5-oxopentanamido]-3-methylbutanamido]-5-fluoro-4-oxopentanoate
• 别名: Biotin-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK; Biotin-D(OMe)E(OMe)VD(OMe)-FMK

产品详细信息

详细说明 (English)

An inhibitor/probe for Caspases-3. A biotinylated derivative of Caspase-3 inhibitor Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK (Cat. No. FK010) that has been esterified to increase cell permeability. Also inhibits caspase-6, caspase-7, and caspase-10. Can be used to purify caspase-3 from cell lysates. The addition of esterase will enhance inhibitory activity in cell-free systems.

参考文献

• Chandler, J. et al., J. Biol. Chem., 273(18):10815 (1998).
• Nicholson, D.W. et al., Nature, 376:37 (1995).