Z-Ile-Glu(OMe)-Thr-Asp(OMe)-Fluoromethylketone

• 产品号: 03FK012
• 分子式: C30H43FN4O11
• 分子量: 654.6810232

产品别名

• 标题: Z-Ile-Glu(OMe)-Thr-Asp(OMe)-Fluoromethylketone
• IUPAC标准名: methyl (3S)-3-[(2S,3R)-2-[(2S)-2-[(2S,3S)-2-{[(benzyloxy)carbonyl]amino}-3-methylpentanamido]-5-methoxy-5-oxopentanamido]-3-hydroxybutanamido]-5-fluoro-4-oxopentanoate
• IUPAC传统名: methyl (3S)-3-[(2S,3R)-2-[(2S)-2-[(2S,3S)-2-{[(benzyloxy)carbonyl]amino}-3-methylpentanamido]-5-methoxy-5-oxopentanamido]-3-hydroxybutanamido]-5-fluoro-4-oxopentanoate
• 别名: Z-IE(OMe)TD(OMe)-FMK; Z-Ile-Glu(OMe)-Thr-Asp(OMe)-FMK

产品详细信息

详细说明 (English)

A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B. When using with purified native or recombinant enzyme, pretreatment with an esterase is required.

参考文献

• Zhuang, S. et al., Exp. Cell. Res., 250(1):203 (1999).