Ac-Trp-Glu-His-Asp-7-Amino-4-trifluoromethylcoumarin

• 产品号: 03AFC156
• 分子式: C38H37F3N8O11
• 分子量: 838.7425896

产品别名

• 标题: Ac-Trp-Glu-His-Asp-7-Amino-4-trifluoromethylcoumarin
• IUPAC标准名: (4S)-4-{[(1S)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-(1H-imidazol-4-yl)ethyl]carbamoyl}-4-[(2S)-2-acetamido-3-(1H-indol-3-yl)propanamido]butanoic acid
• IUPAC传统名: (4S)-4-{[(1S)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-(1H-imidazol-4-yl)ethyl]carbamoyl}-4-[(2S)-2-acetamido-3-(1H-indol-3-yl)propanamido]butanoic acid
• 别名: Ac-WEHD-AFC; Ac-Trp-Glu-His-Asp-AFC

产品详细信息

详细说明 (English)

A fluorogenic substrate for caspase-5 (ICErel-III, TY), caspase-1, and caspase-4. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore.
Excitation max.: ~400 nm, Emission max.: ~505 nm

参考文献

• Thornberry, N.A. et al., J. Biol. Chem., 272:17907 (1997).
• Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.