Ac-Leu-Glu-Val-Asp-7-Amino-4-trifluoromethylcoumarin

• 产品号: 03AFC155
• 分子式: C32H40F3N5O11
• 分子量: 727.6821096

产品别名

• 标题: Ac-Leu-Glu-Val-Asp-7-Amino-4-trifluoromethylcoumarin
• IUPAC标准名: (4S)-4-{[(1S)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(2S)-2-acetamido-4-methylpentanamido]butanoic acid
• IUPAC传统名: (4S)-4-{[(1S)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(2S)-2-acetamido-4-methylpentanamido]butanoic acid
• 别名: Ac-Leu-Glu-Val-Asp-AFC; Ac-LEVD-AFC

产品详细信息

详细说明 (English)

A fluorogenic substrate for Caspase-4 (ICErel-II, TX, ICH-2). Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore. Also serves as a substrate for caspase-1.
Excitation max.: ~400 nm, Emission max.: ~505 nm

参考文献

• Thornberry, N.A. et al., Science, 281:1312 (1998).
• Talanian, R.V. et al., J. Biol. Chem., 272:9677 (1997).
• Lynch, T., et al. 1997. Mol. Psychiatr. 2, 227.
• Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.