Ac-Ile-Glu-Thr-Asp-7-Amino-4-trifluoromethylcoumarin

• 产品号: 03AFC140
• 分子式: C31H38F3N5O12
• 分子量: 729.6549296

产品别名

• 标题: Ac-Ile-Glu-Thr-Asp-7-Amino-4-trifluoromethylcoumarin
• IUPAC标准名: (4S)-4-{[(1S,2R)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-hydroxypropyl]carbamoyl}-4-[(2S,3S)-2-acetamido-3-methylpentanamido]butanoic acid
• IUPAC传统名: (4S)-4-{[(1S,2R)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-hydroxypropyl]carbamoyl}-4-[(2S,3S)-2-acetamido-3-methylpentanamido]butanoic acid
• 别名: Ac-Ile-Glu-Thr-Asp-AFC; Ac-IGTD-AFC

产品详细信息

详细说明 (English)

A fluorogenic substrate for the detection of granzyme B and caspase-8 activity. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore.
Excitation max.: ~400 nm, Emission max.: ~505 nm

参考文献

• Thornberry, N.A. et al., Science, 281:1312 (1998).
• Talanian, R.V. et al., J. Biol. Chem., 272:9677 (1997).
• Karahashi, H., and Amano, F. 2000. Biol. Pharm. Bull. 23, 140.