IBERIOTOXIN

• 产品号: 02158935
• CAS号: 129203-60-7
• 分子式: C179H274N50O55S7
• 分子量: 4230.84786
• 纯 度: 98%
• 保 存: 0°C

产品别名

• 标题: IBERIOTOXIN
• IUPAC标准名: (2R)-4-carbamoyl-2-[(2R)-3-(4-hydroxyphenyl)-2-{[(1S,4R,7S,12S,15S,18S,21S,24S,30S,33S,36S,42S,45R,50S,53S,56S,59S,62S,65S,68R,75S,78S,84S,89R,92R,95S)-15,42,62,75,78-pentakis(4-aminobutyl)-24-benzyl-4,36-bis(3-carbamimidamidopropyl)-50-[(2S)-3-carboxy-2-[(2R)-2-[(2R)-3-carboxy-2-[(2R,3S)-3-hydroxy-2-[(2R)-2-{[(2S)-5-oxopyrrolidin-2-yl]formamido}-3-phenylpropanamido]butanamido]propanamido]-3-methylbutanamido]propanamido]-65-(2-carboxyethyl)-18,33-bis(carboxymethyl)-53,59,92-tris(hydroxymethyl)-89-(1H-indol-3-ylmethyl)-21-(2-methylpropyl)-84-[2-(methylsulfanyl)ethyl]-2,5,13,16,19,22,25,28,31,34,37,40,43,51,54,57,60,63,66,74,77,80,83,86,87,90,93,96-octacosaoxo-30,56,95-tris(propan-2-yl)-9,10,47,48,70,71-hexathia-3,6,14,17,20,23,26,29,32,35,38,41,44,52,55,58,61,64,67,73,76,79,82,85,88,91,94,97-octacosaazatricyclo[43.27.14.11^{12,68}]heptanonacontan-7-yl]formamido}propanamido]butanoic acid
• IUPAC传统名: (2R)-4-carbamoyl-2-[(2R)-3-(4-hydroxyphenyl)-2-{[(1S,4R,7S,12S,15S,18S,21S,24S,30S,33S,36S,42S,45R,50S,53S,56S,59S,62S,65S,68R,75S,78S,84S,89R,92R,95S)-15,42,62,75,78-pentakis(4-aminobutyl)-24-benzyl-4,36-bis(3-carbamimidamidopropyl)-50-[(2S)-3-carboxy-2-[(2R)-2-[(2R)-3-carboxy-2-[(2R,3S)-3-hydroxy-2-[(2R)-2-{[(2S)-5-oxopyrrolidin-2-yl]formamido}-3-phenylpropanamido]butanamido]propanamido]-3-methylbutanamido]propanamido]-65-(2-carboxyethyl)-18,33-bis(carboxymethyl)-53,59,92-tris(hydroxymethyl)-89-(1H-indol-3-ylmethyl)-30,56,95-triisopropyl-21-(2-methylpropyl)-84-[2-(methylsulfanyl)ethyl]-2,5,13,16,19,22,25,28,31,34,37,40,43,51,54,57,60,63,66,74,77,80,83,86,87,90,93,96-octacosaoxo-9,10,47,48,70,71-hexathia-3,6,14,17,20,23,26,29,32,35,38,41,44,52,55,58,61,64,67,73,76,79,82,85,88,91,94,97-octacosaazatricyclo[43.27.14.11^{12,68}]heptanonacontan-7-yl]formamido}propanamido]butanoic acid
• 别名: IBTX (SCORPION, BUTHUS TAMULUS); IBTX; pGlu-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-Gln [Disulfide Bridges: 7?28; 13?33; 17?35]

产品登记号

• CAS号: 129203-60-7

产品性质

• 自燃点: No data
• 沸点: No data
• 密度: No data
• 闪点: No data
• 熔点: No data
• 分配系数: No data
• 蒸汽密度: No data
• 蒸汽压: No data
• 纯度: 98%
• 澳大利亚Hazchem: 2X
• 美国ERG指导号: 153
• 欧盟危险货物分类: T2
• 欧盟危险识别号(EUHIN): 6.1B
• 欧盟危险性物质标志: 剧毒(Highly toxic) (T+)
• 危险公开号: R:25
• RTECS编号: NH6107500
• 安全公开号: S:28-36/37/39-45-53
• 保存条件: 0°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 3172
• 联合国危险货物包装类别(PG): III

产品详细信息

详细说明 (English)

From Buthus tamulus Scorpion
Purity: 98%
More specific than charybdotoxin at inhibiting high conductance Ca2+-activated K+ channel via allosteric inhibition.

参考文献

• Galvez, A., et al., J. Biol. Chem., 265: 11083 (1990)
• Essin, K., et al., BK Channels In Innate Immune Functions Of Neutrophils And Macrophages. Blood 113, 1326-31, (2009)
• Galvez, A., Purification and characterization of a unique potent peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. J. Biol. Chem. 265, 11083, (1990)
• Candia, S. et al., Mode of action of Iberiotoxin, a potent blocker of the large conductance Ca2+-activated K+ channel. Biophys. J. 63, 583-90, (1992)
• Satake, N., et al., The inhibitory effects of iberiotoxin and 4-aminopyridine on the relaxation induced by β1- and β2-adrenoceptor activation in rat aortic rings. Br. J. Pharmacol. 119, 505, (1996)
• Shao, L.R., et al., The role of BK-type Ca2+-dependent K+ channels in spike broadening during repetitive firing in rat hippocampal pyramidal cells. J. Physiol. 521, 135, (1999)
• Merck 14,4874