DIACYLGLYCEROL KINASE INHIBITOR I

• 产品号: 02152409
• CAS号: 93076-89-2
• 分子式: C27H26FN3OS
• 分子量: 459.5782432
• 保 存: Room Temperature (15-30°C)

产品别名

• 标题: DIACYLGLYCEROL KINASE INHIBITOR I
• IUPAC标准名: 6-(2-{4-[(4-fluorophenyl)(phenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one
• IUPAC传统名: 6-(2-{4-[(4-fluorophenyl)(phenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one
• 别名: R59022; 6-[2-[4-[(4-fluorophenyl)phenyl-methylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo-[3,2-a]pyrimidin-5-one; DKI

产品登记号

• CAS号: 93076-89-2

产品性质

• 保存条件: Room Temperature (15-30°C)

产品详细信息

详细说明 (English)

The elevation of diacylglycerol became of major importance when diacylglycerol was shown to stimulate protein kinase C, making this lipid candidate for a second messenger function in the signal transduction system. In intact cells, diacylglycerol is rapidly phosphorylated into phosphatidic acid by diacylglycerol kinase and reverses the protein kinase C activity.
DKI was found to inhibit diacylglycerol kinase. In human red blood cell membranes and in intact platelets, the concentrations needed for half maximal inhibition ranged from 2 to 4x10^-6M.