Alclometasone

• 产品号: DB00240
• CAS号: 66734-13-2
• 分子式: C28H37ClO7
• 分子量: 521.04218

产品别名

• 标题: Alclometasone
• IUPAC标准名: 2-[(1S,2R,9R,10S,11S,13R,14R,15S,17S)-9-chloro-17-hydroxy-2,13,15-trimethyl-5-oxo-14-(propanoyloxy)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-14-yl]-2-oxoethyl propanoate
• IUPAC传统名: modrasone
• 商标名: Aclovate
• 别名: Alclometasone dipropionate

产品登记号

• CAS号: 66734-13-2

产品性质

• 疏水性(logP): 2.7
• 溶解度: Insoluble

产品详细信息

详细说明 (English)

• Drug Groups: approved
• Description: Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent. [Wikipedia]
• Indication: For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
• Pharmacology: Alclometasone is a synthetic corticosteroid for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and antipruritic agents. Alclometasone is a selective glucocorticoid receptor agonist.
• Toxicity: Symptoms of overdose include suppression of adrenal glands, temporary decrease in white blood cell counts, symptoms of hypersensitivity (such as skin rash, hives, itching, and difficulty breathing), and increased susceptibility to infection.
• Affected Organisms: Humans and other mammals
• Biotransformation: Hepatic.
• Absorption: Topical corticosteroids can be absorbed from normal intact skin. Studies have shown that approximately 3% of steroid is absorbed during 8 hours of contact with intact skin of normal volunteers.
• External Links: Wikipedia; RxList; PDRhealth; Drugs.com