Aminophenazone

• 产品号: DB01424
• CAS号: 58-15-1
• 分子式: C13H17N3O
• 分子量: 231.29358

产品别名

• 标题: Aminophenazone
• IUPAC标准名: 4-(dimethylamino)-1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one
• IUPAC传统名: aminophenazone
• 别名: 4-Dimethylaminoantipyrine; Dipyrine; Aminopyrine

产品登记号

• CAS号: 58-15-1
• PubChem CID: 6009
• PubChem SID: 46504975

产品性质

• 疏水性(logP): 1.00 [HANSCH,C ET AL. (1995)]
• 溶解度: 54.4 mg/mL at 30 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

产品详细信息

详细说明 (English)

• Drug Groups: approved; withdrawn
• Description: A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of agranulocytosis. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in liver function tests. [PubChem]
• Indication: Formerly widely used as an antipyretic and analgesic in rheumatism, neuritis, and common colds. Currently used to measure total body water.
• Pharmacology: Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of agranulocytosis. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in liver function tests. [Wikipedia]
• Toxicity: Can cause life-threatening agranulocytosis.
• Affected Organisms: Humans and other mammals
• References: Rating D, Langhans CD: Breath tests: concepts, applications and limitations. Eur J Pediatr. 1997 Aug;156 Suppl 1:S18-23. [Pubmed]
• External Links: Wikipedia

参考文献

• Rating D, Langhans CD: Breath tests: concepts, applications and limitations. Eur J Pediatr. 1997 Aug;156 Suppl 1:S18-23. Pubmed