Item |
Information |
Drug Groups
|
approved |
Description
|
An antineoplastic agent that acts by alkylation. [PubChem] |
Indication |
For the treatment of polycythaemia vera and refractory chronic myeloid leukaemia. |
Pharmacology |
Pipobroman is an antineoplastic agent. Specifically it is a piperazine derivative with a chemical structure close to that of many DNA alkylating agents. Pipobroman has well documented clinical activity against polycythemia vera and essential thrombocythemia. |
Toxicity |
Symptoms of overdose include hematologic toxicity, especially with chronic overdosage. |
Affected Organisms |
• |
Humans and other mammals |
|
Absorption |
Well absorbed from the GI tract. |
External Links |
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