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Iohexol

产品号 DB01362 公司名称 DrugBank
CAS号 66108-95-0 公司网站 http://www.ualberta.ca/
分子式 C19H26I3N3O9 电 话 (780) 492-3111
分子量 821.13785 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 1188

产品价格信息

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产品别名

标题
Iohexol
IUPAC标准名
1-N,3-N-bis(2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodobenzene-1,3-dicarboxamide
IUPAC传统名
iohexol
商标名
Histodenz
Exypaque
Omnipaque
Nycodenz

产品登记号

PubChem CID 3730
CAS号 66108-95-0
PubChem SID 46506178

产品性质

疏水性(logP) -3.05 [HANSCH,C & LEO,AJ (1985)]

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. [PubChem]
Indication Iohexol ia used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures.
Pharmacology Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.
Toxicity Non-ionic radiocontrast agents like iohexol are cytotoxic to renal cells. The toxic effects include apoptosis, cellular energy failure, disruption of calcium homeostasis, and disturbance of tubular cell polarity, and are thought to be linked to oxidative stress.
Affected Organisms
Humans and other mammals
Absorption Small amounts are absorbed through the bladder via intravesical instillation. Following intrauterine instillation, the majority of the medium within the uterine cavity is discharged into the vagina immediately upon termination of procedure. However, any medium retained in the uterine or peritoneal cavity is absorbed systemically within 60 minutes. May not be absorbed for up to 24 hours if tubes are obstructed and dilated.
Half Life Intrathecal half-life is 3.4 hours (mean). Intravascular is approximately 2 hours (with normal renal function).
Elimination Iohexol is absorbed from cerebrospinal fluid (CSF) into the bloodstream and is eliminated by renal excretion. No significant metabolism, deiodination, or biotransformation occurs.
Distribution * 350-849 mL/kg
Clearance * 109 mL/min [Adult patients receiving 16-18 ml of iohexol (180 mgI/mL) by lumbar intrathecal injection]
References
Kawada TK: Iohexol and iopamidol: second-generation nonionic radiographic contrast media. Drug Intell Clin Pharm. 1985 Jul-Aug;19(7-8):525-9. [Pubmed]
Shaw DD, Potts DG: Toxicology of iohexol. Invest Radiol. 1985 Jan-Feb;20(1 Suppl):S10-3. [Pubmed]
External Links
Wikipedia

参考文献

  • Kawada TK: Iohexol and iopamidol: second-generation nonionic radiographic contrast media. Drug Intell Clin Pharm. 1985 Jul-Aug;19(7-8):525-9. Pubmed
  • Shaw DD, Potts DG: Toxicology of iohexol. Invest Radiol. 1985 Jan-Feb;20(1 Suppl):S10-3. Pubmed