| Item |
Information |
|
Drug Groups
|
approved |
|
Description
|
Saprisartan is an AT1 receptor antagonist. It is based on medications of losartan's prototypical chemical structure. The mode of (functional) AT1 receptor antagonism has been characterized as insurmountable/noncompetitive for saprisartan. It is very likely that slow dissociation kinetics from the AT1 receptor underlie insurmountable antagonism.(10579749) |
| Indication |
Saprisartan is used in the treatment of hypertension and heart failure. |
| Pharmacology |
By inhibiting the angiotensin II receptor, this drug leades to a decrease in sodium reabsorption and a decrease in vasoconstriction. This has the combined effect of decreasing blood pressure. |
| Affected Organisms |
| • |
Humans and other mammals |
|