Pancuronium

• 产品号: DB01337
• CAS号: 15500-66-0
• 分子式: C35H60N2O4++
• 分子量: 572.8619

产品别名

• 标题: Pancuronium
• IUPAC标准名: 1-[(1S,2S,4S,5S,7S,10R,11S,13S,14R,15S)-5,14-bis(acetyloxy)-2,15-dimethyl-4-(1-methylpiperidin-1-ium-1-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-13-yl]-1-methylpiperidin-1-ium
• IUPAC传统名: 1-[(1S,2S,4S,5S,7S,10R,11S,13S,14R,15S)-5,14-bis(acetyloxy)-2,15-dimethyl-4-(1-methylpiperidin-1-ium-1-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-13-yl]-1-methylpiperidin-1-ium
• 商标名: Pavulon; Mioblock
• 别名: Pancuronium bromide; Bromure de pancuronium [inn-french]; Bromuro de pancuronio [inn-spanish]; Pancuronium dibromide

产品登记号

• CAS号: 15500-66-0
• PubChem SID: 46506118
• PubChem CID: 441289

产品性质

• 溶解度: 500 mg/mL [MERCK INDEX (1996)]

产品详细信息

详细说明 (English)

• Drug Groups: approved
• Description: A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than curare but has less effect on the circulatory system and on histamine release.
• Indication: Used as a muscle relaxant during anesthesia and surgical procedures.
• Pharmacology: Pancuronium is a typical non-depolarising curare-mimetic muscle relaxant. It acts as a competitive acetylcholine antagonist on neuromuscular junctions, displacing acetylcholine (hence competitive) from its post-synaptic nicotinic acetylcholine receptors. It is, unlike suxamethonium, a non-depolarising agent, which means, that it causes no spontaneous depolarisations upon association with the nicotinic receptor in neuromuscular junction, thus producing no muscle fasciculations upon administration. Pancuronium has no hormonal activity. It exerts slight vagolytic activity (i.e. diminishing activity of the vagus nerve) and no ganglioplegic (i.e., blocking ganglions) activity.
• Affected Organisms: Humans and other mammals
• Biotransformation: Hepatic.
• Half Life: 1.5 to 2.7 hours.
• Protein Binding: 77 to 91%
• Distribution: * 241 to 280 mL/kg
• Clearance: * Plasma cl=1.1–1.9 mL/minute/kg
• External Links: Wikipedia