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Cefoperazone

产品号 DB01329 公司名称 DrugBank
CAS号 62893-19-0 公司网站 http://www.ualberta.ca/
分子式 C25H27N9O8S2 电 话 (780) 492-3111
分子量 645.66738 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 1163

产品价格信息

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产品别名

标题
Cefoperazone
IUPAC标准名
(6R,7R)-7-{2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetamido}-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
IUPAC传统名
(6R,7R)-7-[2-(4-ethyl-2,3-dioxopiperazine-1-carbonylamino)-2-(4-hydroxyphenyl)acetamido]-3-{[(1-methyl-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
商标名
Cefobid
别名
Cefoperazono [inn-spanish]
Cefoperazonum [inn-latin]

产品登记号

PubChem CID 44185
CAS号 62893-19-0
PubChem SID 46504543

产品性质

疏水性(logP) -0.74 [HANSCH,C ET AL. (1995)]

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It has been proposed especially against Pseudomonas infections.
Indication For the treatment of bacterial infections caused by susceptible microorganisms.
Pharmacology Cefoperazone is a third generation cephalosporin antibiotic. Cefoperazone exerts its bactericidal effect by inhibiting the bacterial cell wall synthesis
Toxicity Symptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting.
Affected Organisms
Enteric bacteria and other eubacteria
Biotransformation No significant quanitity of metabolites have been identified in urine.
Half Life The mean serum half-life is approximately 2.0 hours, independent of the route of administration.
Protein Binding The degree of reversible protein binding varies with the serum concentration from 93% at 25 mcg/mL to 90% at 250 mcg/mL and 82% at 500 mcg/mL. Cefotetan is 88% plasma protein bound.
Elimination Cefoperazone is excreted mainly in the bile.
References
Jones RN, Barry AL: Cefoperazone: a review of its antimicrobial spectrum, beta-lactamase stability, enzyme inhibition, and other in vitro characteristics. Rev Infect Dis. 1983 Mar-Apr;5 Suppl 1:S108-26. [Pubmed]
External Links
Wikipedia

参考文献

  • Jones RN, Barry AL: Cefoperazone: a review of its antimicrobial spectrum, beta-lactamase stability, enzyme inhibition, and other in vitro characteristics. Rev Infect Dis. 1983 Mar-Apr;5 Suppl 1:S108-26. Pubmed