| Item |
Information |
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Drug Groups
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approved |
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Description
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Cefamandole (INN, also known as cephamandole) is a broad-spectrum cephalosporin antibiotic. The clinically used form of cefamandole is the formate ester cefamandole nafate, a prodrug which is administered parenterally. Cefamandole is no longer available in the United States. |
| Indication |
For the treatment of serious infections caused by susceptible strains of microorganisms. |
| Pharmacology |
Cefamandole is a broad-spectrum cephalosporin antibiotic. The clinically used form of cefamandole is the formate ester cefamandole nafate, a prodrug which is administered parenterally. The bactericidal action of cefamandole results from inhibition of cell-wall synthesis. Cephalosporins have in vitro activity against a wide range of gram-positive and gram-negative organisms. |
| Toxicity |
Symptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting. |
| Affected Organisms |
| • |
Enteric bacteria and other eubacteria |
|
| Half Life |
The half-life after an intravenous dose is 32 minutes; after intramuscular administration, the half-life is 60 minutes. |
| Protein Binding |
75% |
| External Links |
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