Cefotiam

• 产品号: DB00229
• CAS号: 61622-34-2
• 分子式: C18H23N9O4S3
• 分子量: 525.62812

产品别名

• 标题: Cefotiam
• IUPAC标准名: (6R,7R)-7-[2-(2-amino-1,3-thiazol-4-yl)acetamido]-3-[({1-[2-(dimethylamino)ethyl]-1H-1,2,3,4-tetrazol-5-yl}sulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• IUPAC传统名: cefotiam
• 商标名: Ceradon
• 别名: Cefotiamum [INN-Latin]; CTM; Cefotiam hydrochloride

产品登记号

• PubChem CID: 43708
• PubChem SID: 46506679
• CAS号: 61622-34-2

产品性质

• 溶解度: Soluble
• 疏水性(logP): -2.1

产品详细信息

详细说明 (English)

• Drug Groups: approved
• Description: One of the cephalosporins that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms. [PubChem]
• Indication: For treatment of severe infections caused by susceptible bacteria.
• Pharmacology: Cefotiam is a third generation beta-lactam cephalosporin antibiotic. It has broad spectrum activity against Gram positive and Gram negative bacteria. It does not have activity against Pseudomonas aeruginosa. Cefotiam works by inhibiting bacterial cell wall biosynthesis.
• Toxicity: Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions.
• Affected Organisms: Enteric bacteria and other eubacteria
• Absorption: Rapidly absorbed following intramuscular injection. Bioavailability is 60% following intramuscular injection.
• Half Life: Approximately 1 hour.
• Protein Binding: 40%
• References: Muller R, Bottger C, Wichmann G: Suitability of cefotiam and cefuroxime axetil for the perioperative short-term prophylaxis in tonsillectomy patients. Arzneimittelforschung. 2003;53(2):126-32. [Pubmed] ; Kolben M, Mandoki E, Ulm K, Freitag K: Randomized trial of cefotiam prophylaxis in the prevention of postoperative infectious morbidity after elective cesarean section. Eur J Clin Microbiol Infect Dis. 2001 Jan;20(1):40-2. [Pubmed] ; Shimizu S, Chen KR, Miyakawa S: Cefotiam-induced contact urticaria syndrome: an occupational condition in Japanese nurses. Dermatology. 1996;192(2):174-6. [Pubmed]
• External Links: Wikipedia

参考文献

• Muller R, Bottger C, Wichmann G: Suitability of cefotiam and cefuroxime axetil for the perioperative short-term prophylaxis in tonsillectomy patients. Arzneimittelforschung. 2003;53(2):126-32. Pubmed
• Kolben M, Mandoki E, Ulm K, Freitag K: Randomized trial of cefotiam prophylaxis in the prevention of postoperative infectious morbidity after elective cesarean section. Eur J Clin Microbiol Infect Dis. 2001 Jan;20(1):40-2. Pubmed
• Shimizu S, Chen KR, Miyakawa S: Cefotiam-induced contact urticaria syndrome: an occupational condition in Japanese nurses. Dermatology. 1996;192(2):174-6. Pubmed