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Chlorprothixene

产品号 DB01239 公司名称 DrugBank
CAS号 113-59-7 公司网站 http://www.ualberta.ca/
分子式 C18H18ClNS 电 话 (780) 492-3111
分子量 315.86022 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 1108

产品价格信息

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产品别名

标题
Chlorprothixene
IUPAC标准名
[3-(2-chloro-9H-thioxanthen-9-ylidene)propyl]dimethylamine
IUPAC传统名
chlorprothixene
商标名
Trictal
Traquilan
Truxal
Paxyl
Rentovet
Taractan
Tarasan
Truxaletten
Vetacalm
Iaractan
Tactaran
Tardan
Truxil
别名
Chlorprothixen
CPT
Cis-Chlorprothixene
Chlorprotixine
Chlothixen
CPX
Alpha-Chlorprothixene
Chloroprothixene
Chlorprothixine
Chlorprotixen
Chlorprotixene

产品登记号

CAS号 113-59-7

产品性质

疏水性(logP) 5.2
溶解度 0.295 mg/L

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description Chlorprothixene is a typical antipsychotic drug of the thioxanthene (tricyclic) class. Chlorprothixene exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.
Indication For treatment of psychotic disorders (e.g. schizophrenia) and of acute mania occuring as part of bipolar disorders.
Pharmacology Chlorprothixene is a typical antipsychotic drug of the thioxanthine class. It has a low antipsychotic potency (half to 2/3 of chlorpromazine). An intrinsic antidepressant effect of chlorprothixene has been discussed, but not proven yet. Likewise, it is unclear, if chlorprothixene has genuine analgesic effects. An antiemetic effect, as with most antipsychotics, exists. It is used in the treatment of nervous, mental, and emotional conditions. Improvement in such conditions is thought to result from the effect of the medicine on nerve pathways in specific areas of the brain. Chlorprothixene has a strong sedative activity with a high incidence of anticholinergic side-effects. Chlorprothixene is structurally related to chlorpromazine, with which it shares in principal all side effects. Allergic side-effects and liver damage seem to appear with an appreciable lower frequency.
Toxicity Symptoms of overdose include difficulty in breathing (severe), dizziness (severe), drowsiness (severe), muscle trembling, jerking, stiffness, or uncontrolled movements (severe), small pupils, unusual excitement, and unusual tiredness or weakness (severe).
Affected Organisms
Humans and other mammals
Biotransformation Hepatic
Absorption Incomplete bioavailability.
Half Life 8 to 12 hours
External Links
Wikipedia

参考文献