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Levomethadyl Acetate

产品号 DB01227 公司名称 DrugBank
CAS号 1477-40-3 公司网站 http://www.ualberta.ca/
分子式 C23H31NO2 电 话 (780) 492-3111
分子量 353.49774 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 1096

产品价格信息

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产品别名

标题
Levomethadyl Acetate
IUPAC标准名
(3S,6S)-6-(dimethylamino)-4,4-diphenylheptan-3-yl acetate
IUPAC传统名
levomethadyl acetate
商标名
Orlaam
别名
1-alpha-acetylmethadol
Nor-LAAM
Levo-Alphacetylmethadol
Levacetylmethadol
LAAM
Levacetilmetadol [INN-Spanish]
Levacetylmethadolum [INN-Latin]
Levo-Methadyl Acetate
Levomethadyl

产品登记号

PubChem CID 15130
PubChem SID 46507749
CAS号 1477-40-3

产品性质

疏水性(logP) 5.4
溶解度 >15 mg/mL

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description A narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. [PubChem]
Indication For the treatment and management of opiate dependence. It is sometimes used to treat severe pain in terminal patients.
Pharmacology Levomethadyl acetate (also known as LAAM) is a synthetic synthetic opioid analgesic with multiple actions quantitatively similar to those as morphine, the most prominent of which involve the central nervous system and organs composed of smooth muscle. However, levomethadyl acetate is more active and more toxic than morphine. The principal actions of therapeutic value are analgesia and sedation and detoxification or temporary maintenance in narcotic addiction. In this respect, the drug is similar to Methadone and also has structural similarities to it. The levomethadyl acetate abstinence syndrome, although qualitatively similar to that of morphine, differs in that the onset is slower, the course is more prolonged, and the symptoms are less severe.
Toxicity Signs of overdose include apnea, circulatory collapse, pulmonary edema, cardiac arrest, and death.
Affected Organisms
Humans and other mammals
Biotransformation Levomethadyl acetate undergoes extensive first-pass metabolism to the active demethylated metabolite nor-levomethadyl acetate, which is further demethylated to a second active metabolite, dinor-levomethadyl acetate. These metabolites are more potent than the parent drug.
Absorption Levomethadyl acetate is rapidly absorbed from an oral solution.
Half Life 2.6 days
Protein Binding Approximately 80%
External Links
Wikipedia
RxList
Drugs.com

参考文献