Item |
Information |
Drug Groups
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approved |
Description
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Aminophylline is a drug combination that contains theophylline and ethylenediamine in 2:1 ratio. [Wikipedia] |
Indication |
For the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis. |
Pharmacology |
Aminophylline is the ethylenediamine salt of theophylline. Theophylline stimulates the CNS, skeletal muscles, and cardiac muscle. It relaxes certain smooth muscles in the bronchi through PDE3 inhibition, produces diuresis, and causes an increase in gastric secretion. |
Affected Organisms |
• |
Humans and other mammals |
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Half Life |
7-9 hours |
Protein Binding |
60% |
Distribution |
* 0.3 to 0.7 L/kg |
Clearance |
* 0.29 mL/kg/min [postnatal age 3-15 days] * 0.64 mL/kg/min [postnatal age 25-57 days] * 1.7 mL/kg/min [?1-4 years] * 1.6 mL/kg/min [4-12 years] * 0.9 mL/kg/min [13-15 years] * 1.4 mL/kg/min [16-17 years] * 0.65 mL/kg/min [Adults (16-60 years), non-smoking asthmatics] * 0.41 mL/kg/min [Elderly (>60 years). liver, and renal function] * 0.33 mL/kg/min [Acute pulmonary edema] * 0.54 mL/kg/min [COPD->60 years, stable non-smoker >1 year] * 0.48 mL/kg/min [COPD with cor pulmonale] * 1.25 mL/kg/min [Cystic fibrosis (14-28 years)] * 0.31 mL/kg/min [Liver disease -cholestasis] * 0.35 mL/kg/min [cirrhosis] * 0.65 mL/kg/min [acute hepatitis] * 0.47 mL/kg/min [Sepsis with multi-organ failure] * 0.38 mL/kg/min [hypothyroid] * 0.8 mL/kg/min [hyperthyroid] |
External Links |
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