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Aminophylline

产品号 DB01223 公司名称 DrugBank
CAS号 317-34-0 公司网站 http://www.ualberta.ca/
分子式 C16H24N10O4 电 话 (780) 492-3111
分子量 420.42636 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 1093

产品价格信息

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产品别名

标题
Aminophylline
IUPAC标准名
bis(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione); ethane-1,2-diamine
IUPAC传统名
ethylenediamine; bis(theophylline)
商标名
Theolone
Somophyllin O
Rectalad-Aminophylline
Diuxanthine
Aminodur
Cardiomin
Cardophyllin
Diaphylline
Etilen-Xantisan Tabl.
Genophyllin
Methophylline
Phylcardin
Rectalad Aminophylline
Somophyllin
Theophyllin Ethylenediamine
Variaphylline
Aminocardol
Ammophyllin
Cardiofilina
Cardophylin
Diophllin
Dobo
Dura-Tab S.M. Aminophylline
Ethophylline
Eurphyllin
Euufillin
Grifomin
Lasodex
Metaphyllin
Norofilina
Phyllindon
Theolamine
Theophyldine
Theophyllamine
Theophyllin Aethylendiamin
Theophylline Ethylenediamine
Truphylline
Vasofilina
Carena
Cariomin
Inophylline
Linampheta
Lixaminol
Metaphylline
Minaphil
Miofilin
Neophyiline
Peterphyllin
Phyllocontin
Phyllocontin-350
Somophyllin-O
Stenovasan
Syntophyllin
Theodrox
Theophyline Ethylenediamine
Theophyllaminum
Thephyldine
别名
Aminophylline Anhydrous
Aminophyllin
Aminophylline Dihydrate
Aminophylline Dye Free

产品登记号

PubChem SID 46508784
PubChem CID 9433
CAS号 317-34-0

产品性质

疏水性(logP) -3.03
溶解度 2E+005 mg/L

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description Aminophylline is a drug combination that contains theophylline and ethylenediamine in 2:1 ratio. [Wikipedia]
Indication For the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis.
Pharmacology Aminophylline is the ethylenediamine salt of theophylline. Theophylline stimulates the CNS, skeletal muscles, and cardiac muscle. It relaxes certain smooth muscles in the bronchi through PDE3 inhibition, produces diuresis, and causes an increase in gastric secretion.
Affected Organisms
Humans and other mammals
Half Life 7-9 hours
Protein Binding 60%
Distribution * 0.3 to 0.7 L/kg
Clearance * 0.29 mL/kg/min [postnatal age 3-15 days]
* 0.64 mL/kg/min [postnatal age 25-57 days]
* 1.7 mL/kg/min [?1-4 years]
* 1.6 mL/kg/min [4-12 years]
* 0.9 mL/kg/min [13-15 years]
* 1.4 mL/kg/min [16-17 years]
* 0.65 mL/kg/min [Adults (16-60 years), non-smoking asthmatics]
* 0.41 mL/kg/min [Elderly (>60 years). liver, and renal function]
* 0.33 mL/kg/min [Acute pulmonary edema]
* 0.54 mL/kg/min [COPD->60 years, stable non-smoker >1 year]
* 0.48 mL/kg/min [COPD with cor pulmonale]
* 1.25 mL/kg/min [Cystic fibrosis (14-28 years)]
* 0.31 mL/kg/min [Liver disease -cholestasis]
* 0.35 mL/kg/min [cirrhosis]
* 0.65 mL/kg/min [acute hepatitis]
* 0.47 mL/kg/min [Sepsis with multi-organ failure]
* 0.38 mL/kg/min [hypothyroid]
* 0.8 mL/kg/min [hyperthyroid]
External Links
Wikipedia
Drugs.com

参考文献