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Indinavir

产品号 DB00224 公司名称 DrugBank
CAS号 150378-17-9 公司网站 http://www.ualberta.ca/
分子式 C36H47N5O4 电 话 (780) 492-3111
分子量 613.78948 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 109

产品价格信息

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产品别名

标题
Indinavir
IUPAC标准名
(2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]carbamoyl}butyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide
IUPAC传统名
indinavir
商标名
Crixivan
别名
Compound J
Indinavir sulfate

产品登记号

CAS号 150378-17-9
PubChem CID 5362440
PubChem SID 46506442

产品性质

疏水性(logP) 2.9
溶解度 0.015 mg/ml

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]
Indication Indinavir is an antiretroviral drug for the treatment of HIV infection.
Pharmacology Indinavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Indinavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs.
Toxicity Symptoms of overdose include myocardial infarction and angina pectoris.
Affected Organisms
Human Immunodeficiency Virus
Biotransformation Hepatic. Seven metabolites have been identified, one glucuronide conjugate and six oxidative metabolites. In vitro studies indicate that cytochrome P-450 3A4 (CYP3A4) is the major enzyme responsible for formation of the oxidative metabolites.
Absorption Rapidly absorbed
Half Life 1.8 (± 0.4) hours
Protein Binding 60%
Elimination Less than 20% of indinavir is excreted unchanged in the urine.
External Links
Wikipedia
RxList
Drugs.com

参考文献