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Ceftriaxone

产品号 DB01212 公司名称 DrugBank
CAS号 73384-59-5 公司网站 http://www.ualberta.ca/
分子式 C18H18N8O7S3 电 话 (780) 492-3111
分子量 554.57992 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 1082

产品价格信息

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产品别名

标题
Ceftriaxone
IUPAC标准名
(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
IUPAC传统名
@ceftriaxone
商标名
Biotrakson
Rocephine
别名
Ceftriaxonum [INN-Latin]
Ceftriaxona [INN-Spanish]
Cefatriaxone
Ceftriazone

产品登记号

CAS号 73384-59-5
PubChem SID 46506458
PubChem CID 5479530

产品性质

疏水性(logP) -1.7

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears. [PubChem]
Indication For the treatment of the infections (respiratory, skin, soft tissue, UTI, ENT) caused by S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph
Pharmacology Ceftriaxone is a cephalosporin/cephamycin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. Ceftriaxone has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Ceftriaxone results from the inhibition of cell wall synthesis and is mediated through Ceftriaxone binding to penicillin binding proteins (PBPs). Ceftriaxone is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
Affected Organisms
Enteric bacteria and other eubacteria
Half Life 5.8-8.7 hours
Protein Binding 95%
Elimination Thirty-three percent to 67% of a ceftriaxone dose was excreted in the urine as unchanged drug and the remainder was secreted in the bile and ultimately found in the feces as microbiologically inactive compounds.
Distribution * 5.78 to 13.5 L
Clearance * 0.58 - 1.45 L/h [healthy adults receiving 0.15-3 g of CEFTRIAXONE]
External Links
Wikipedia
RxList
Drugs.com

参考文献