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Dexfenfluramine

产品号 DB01191 公司名称 DrugBank
CAS号 3239-44-9 公司网站 http://www.ualberta.ca/
分子式 C12H16F3N 电 话 (780) 492-3111
分子量 231.2573496 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 456

产品价格信息

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产品别名

标题
Dexfenfluramine
IUPAC标准名
ethyl({1-[3-(trifluoromethyl)phenyl]propan-2-yl})amine
IUPAC传统名
fenfluramine
商标名
Adifax
Redux
别名
Levofenfluramina [Spanish]
Dextrofenfluramine
Dexfenfluramina [Spanish]
Levofenfluraminum [Latin]
Levofenfluramine [INN]
Levofenfluramine
L-Fenfluramine
Dexfenfluraminum [Latin]
D-Fenfluramine
Dexafenfluramine
Dexfenfluramine Hydrochloride

产品登记号

CAS号 3239-44-9

产品性质

疏水性(logP) 3.5

产品详细信息

详细说明 (English)
Item Information
Drug Groups illicit; approved; withdrawn
Description Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. It was for some years in the mid-1990s approved by the United States Food and Drug Administration for the purposes of weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was withdrawn.
Indication For the management of obesity including weight loss and maintenance of weight loss in patients on a reduced calorie diet
Pharmacology Used to treat diabetes and obesity, Dexfenfluramine decreases caloric intake by increasing serotonin levels in the brain’s synapses. Dexfenfluramine acts as a serotonin reuptake inhibitor. It also causes release of serotonin from the synaptosomes.
Toxicity Symptoms of overdose include respiratory failure and cardiac arrest leading to death.
Affected Organisms
Humans and other mammals
Absorption Well-absorbed from the gastrointestinal tract.
Half Life 17-20 hours
Protein Binding 36%
External Links
Wikipedia
RxList

参考文献