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Desflurane

产品号 DB01189 公司名称 DrugBank
CAS号 57041-67-5 公司网站 http://www.ualberta.ca/
分子式 C3H2F6O 电 话 (780) 492-3111
分子量 168.0377992 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 1060

产品价格信息

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产品别名

标题
Desflurane
IUPAC标准名
2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane
IUPAC传统名
desflurane
商标名
Suprane
别名
Desfluranum [INN-Latin]
Desflurano [INN-Spanish]

产品登记号

PubChem SID 46505270
PubChem CID 42113
CAS号 57041-67-5

产品性质

疏水性(logP) 1.9
溶解度 Negligible

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description Desflurane is a highly fluorinated methyl ethyl ether used for maintenance of general anaesthesia. Volatile agents such as desflurane may activate GABA channels and hyperpolarize cell membranes. In addition, they may inhibit certain calcium channels and therefore prevent release of neurotransmitters and inhibit glutamate channels. Volatile anesthetics easily partition into cellular membranes and could expand the volume of the cell membrane and subsequently distort channels necessary for sodium ion flux and the development of action potentials necessary for synaptic transmission. Desflurane preconditions human myocardium against ischemia through activation of mitochondrial K(ATP) channels, adenosine A1 receptor, and alpha and beta adrenoceptors.
Indication For use as an inhalation agent for induction and/or maintenance of anesthesia for inpatient and outpatient surgery in adults.
Pharmacology Desflurane is a general inhalation anesthetic. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.
Affected Organisms
Humans and other mammals
Biotransformation Minimally biotransformed in the liver in humans (approximately 0.02% of the quantity absorbed).
Absorption Rapidly absorbed into the circulation via the lungs following inhalation.
External Links
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RxList
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