您当前所在的位置:首页 > 产品中心 > 产品信息
Domperidone_分子结构_CAS_57808-66-9)
点击图片或这里关闭

Domperidone

产品号 DB01184 公司名称 DrugBank
CAS号 57808-66-9 公司网站 http://www.ualberta.ca/
分子式 C22H24ClN5O2 电 话 (780) 492-3111
分子量 425.91126 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 1055

产品价格信息

请登录

产品别名

标题
Domperidone
IUPAC标准名
5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)propyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
IUPAC传统名
motilium
商标名
Lopac-D-122
Motilium
Nauzelin

产品登记号

CAS号 57808-66-9
PubChem CID 3151
PubChem SID 46508314

产品性质

疏水性(logP) 2.4
溶解度 0.986 mg/L

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. [PubChem]
Indication For management of dyspepsia, heartburn, epigastric pain, nausea, and vomiting.
Pharmacology Domperidone is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
Toxicity Side effects include galactorrhea, gynecomastia, or menstrual irregularities.
Affected Organisms
Humans and other mammals
Absorption Fast
Half Life 7 hours
Protein Binding 91%-93%
References
Silvers D, Kipnes M, Broadstone V, Patterson D, Quigley EM, McCallum R, Leidy NK, Farup C, Liu Y, Joslyn A: Domperidone in the management of symptoms of diabetic gastroparesis: efficacy, tolerability, and quality-of-life outcomes in a multicenter controlled trial. DOM-USA-5 Study Group. Clin Ther. 1998 May-Jun;20(3):438-53. [Pubmed]
External Links
Wikipedia

参考文献

  • Silvers D, Kipnes M, Broadstone V, Patterson D, Quigley EM, McCallum R, Leidy NK, Farup C, Liu Y, Joslyn A: Domperidone in the management of symptoms of diabetic gastroparesis: efficacy, tolerability, and quality-of-life outcomes in a multicenter controlled trial. DOM-USA-5 Study Group. Clin Ther. 1998 May-Jun;20(3):438-53. Pubmed