Rescinnamine

• 产品号: DB01180
• CAS号: 24815-24-5
• 分子式: C35H42N2O9
• 分子量: 634.71598

产品别名

• 标题: Rescinnamine
• IUPAC标准名: methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-{[3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]oxy}-3,13-diazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{15,20}]henicosa-2(10),4,6,8-tetraene-19-carboxylate
• IUPAC传统名: rescinnamine
• 商标名: Paresinan; Rescisan; Apolon; Rescidan; Anapral; Anaprel; Apoterin S; Cinamine; Cinnasil; Raurescin; Rescinpal; Tuareg; Apoterin; Cartric; Cinatabs; Cinnaloid; Moderil; Normorescina; Raupyrol; Raurescine; Recitensina; Rescaloid; Rescamin; Rescin; Rescitens; Resealoid; Resipal; Reskinnamin; Rozex; Scinnamina; Tenamine; Tsuruselpi S
• 别名: Recinnamine; Reserpinine; Methyl Trimethoxycinnamoylreserpate; Trimethoxycinnamoyl Methyl Reserpate; Rescinnamin; Reserpinene; Reserpinin

产品登记号

• CAS号: 24815-24-5
• PubChem CID: 5280954
• PubChem SID: 46507786

产品性质

• 疏水性(logP): 3.5

产品详细信息

详细说明 (English)

• Drug Groups: approved
• Description: Rescinnamine is an angiotensin-converting enzyme inhibitor used as an antihypertensive drug. It is an alkaloid obtained from Rauwolfia serpentina and other species of Rauwolfia. [Wikipedia]
• Indication: For the treatment of hypertension.
• Pharmacology: Used to treat hypertension. Rescinnamine inhibits angiotensin-converting enzyme. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex and general vasoconstriction, both of which lead to increases vascular resistance. By inhibiting angiotensin II, aldosterone reabsorption is decreased as well as vasoconstriction. This combined effect serves to decrease blood pressure.
• Affected Organisms: Humans and other mammals
• External Links: Wikipedia