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Arsenic trioxide

产品号 DB01169 公司名称 DrugBank
CAS号 1327-53-3 公司网站 http://www.ualberta.ca/
分子式 As2O3 电 话 (780) 492-3111
分子量 197.8414 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 1040

产品价格信息

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产品别名

标题
Arsenic trioxide
IUPAC标准名
bicyclo[1.1.1]diarsoxane
IUPAC传统名
arsenic trioxide
商标名
Arsenite
Trisenox
Arsenolite
Arsodent
Claudelite
Claudetite
别名
Arsenic Oxide
Diarsenic Trioxide
Anhydride Arsenieux [French]
Arsenous Oxide Anhydride
White Arsenic
Arsenic Trioxide [UN1561] [Poison]
Arsenic, White
Arsenic Oxidearsenous Trioxide
Arsenigen Saure [German]
Arsenious Acid Anhydride
Arsenous Anhydride
Arsenous Oxide
Oxyde Arsenieux [ISO-French]
Crude Arsenic
arsenic trioxide
Arsenic Sesquioxide
Arsenic Blanc [French]
Arseni Trioxydum
Acide Arsenieux [French]
Arsenious Acid
Arsenious Oxide
Arsenious Trioxide
Arsenous Acid
Arsenous Acid Anhydride
Arsentrioxide
Di-Arsenic Trioxide
Diarsonic Trioxide
Poison Flour
HSDB 419
Arsenicum Album

产品登记号

PubChem CID 518740
PubChem SID 46506448
CAS号 1327-53-3

产品性质

溶解度 17 mg/mL at 16 oC [SHIU,WY et al. (1990)]

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved; investigational
Description Arsenic trioxide is a chemotheraputic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. Due to the toxic nature of arsenic, this drug carries significant health risks. The enzyme thioredoxin reductase has recently been identified as a target for arsenic trioxide.
Indication For induction of remission and consolidation in patients with acute promyelocytic leukemia (APL), and whose APL is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression
Pharmacology Arsenic Trioxide is indicated for induction of remission and consolidation in patients with acute promyelocytic leukemia (APL) who are refractory to, or have relapsed from, retinoid and anthracycline chemotherapy.
Toxicity Symptoms of overdose include convulsions, muscle weakness and confusion.
Affected Organisms
Humans and other mammals
Biotransformation The metabolism of arsenic trioxide involves reduction of pentavalent arsenic to trivalent arsenic by arsenate reductase and methylation of trivalent arsenic to monomethylarsonic acid and monomethylarsonic acid to dimethylarsinic acid by methyltransferases. The main site of methylation reactions appears to be the liver. Arsenic is stored mainly in liver, kidney, heart, lung, hair and nails.
Protein Binding 75% bound
Elimination Trivalent arsenic is mostly methylated in humans and excreted in urine.
References
Lu J, Chew EH, Holmgren A: Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12288-93. Epub 2007 Jul 18. [Pubmed]
External Links
Wikipedia
RxList
Drugs.com

参考文献

  • Lu J, Chew EH, Holmgren A: Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12288-93. Epub 2007 Jul 18. Pubmed