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Chloroprocaine

产品号 DB01161 公司名称 DrugBank
CAS号 133-16-4 公司网站 http://www.ualberta.ca/
分子式 C13H19ClN2O2 电 话 (780) 492-3111
分子量 270.75516 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 1032

产品价格信息

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产品别名

标题
Chloroprocaine
IUPAC标准名
2-(diethylamino)ethyl 4-amino-2-chlorobenzoate
IUPAC传统名
chloroprocaine
商标名
Nesacaine-CE
Halestyn
Nesacaine-MPF
别名
Chlorprocaine
Chloroprocain
Chloroprocaine hydrochloride

产品登记号

PubChem SID 46508245
CAS号 133-16-4
PubChem CID 8612

产品性质

疏水性(logP) 2.5
溶解度 0.665 mg/mL

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description Chloroprocaine hydrochloride is a local anesthetic given by injection during surgical procedures and labor and delivery. Chloroprocaine, like other local anesthetics, blocks the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse and by reducing the rate of rise of the action potential.
Indication For the production of local anesthesia by infiltration and peripheral nerve block. They are not to be used for lumbar or caudal epidural anesthesia.
Pharmacology Chloroprocaine is an anesthetic agent indicated for production of local or regional anesthesia, particularly for oral surgery. Chloroprocaine (like cocaine) has the advantage of constricting blood vessels which reduces bleeding, unlike other local anesthetics like lidocaine. Chloroprocaine is an ester anesthetic.
Toxicity In mice, the intravenous LD50 of chloroprocaine HCl is 97 mg/kg and the subcutaneous LD50 of chloroprocaine HCl is 950 mg/kg.
Affected Organisms
Humans and other mammals
Biotransformation Chloroprocaine is rapidly metabolized in plasma by hydrolysis of the ester linkage by pseudocholinesterase.
Absorption The rate of systemic absorption of local anesthetic drugs is dependent upon the total dose and concentration of drug administered, the route of administration, the vascularity of the administration site, and the presence or absence of epinephrine in the anesthetic injection.
Half Life 21 +/- 2 seconds
Elimination Chloroprocaine is rapidly metabolized in plasma by hydrolysis of the ester linkage by pseudocholinesterase. Urinary excretion is affected by urinary perfusion and factors affecting urinary pH.
External Links
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