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Flavoxate

产品号 DB01148 公司名称 DrugBank
CAS号 15301-69-6 公司网站 http://www.ualberta.ca/
分子式 C24H25NO4 电 话 (780) 492-3111
分子量 391.4596 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 1019

产品价格信息

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产品别名

标题
Flavoxate
IUPAC标准名
2-(piperidin-1-yl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate
IUPAC传统名
flavoxate
商标名
Urispas
别名
Flavoxate HCI
Flavoxate HCL

产品登记号

CAS号 15301-69-6
PubChem CID 3354
PubChem SID 46505138

产品性质

疏水性(logP) 4.4
溶解度 10 mg/L

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist. [PubChem]
Indication For symptomatic relief of dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence as may occur in cystitis, prostatitis, urethritis, urethrocystitis/urethrotrigonitis.
Pharmacology Flavoxate is a spasmolytic flavone derivative that acts by relaxing the smooth muscle in the urinary tract. Flavoxate is a competitive muscarinic receptor antagonist indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency. Muscarinic receptors play an important role in several major cholin-ergically mediated functions, including contractions of urinary bladder smooth muscle and stimulation of salivary secretion.
Toxicity The oral LD50 for flavoxate HCl in rats is 4273 mg/kg. The oral LD50 for flavoxate HCl in mice is 1837 mg/kg. Symptoms of overdose include convulsions, decreased ability to sweat, (warm, red skin, dry mouth, and increased body temperature), hallucinations, increased heart rate and blood pressure, and mental confusion.
Affected Organisms
Humans and other mammals
Absorption Well absorbed from gastrointestinal tract.
Elimination 57% of the flavoxate HCl was excreted in the urine within 24 hours.
External Links
Wikipedia
RxList
PDRhealth
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参考文献