| Item |
Information |
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Drug Groups
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approved |
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Description
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A semi-synthetic antibiotic that is a chlorinated derivative of oxacillin. [PubChem] |
| Indication |
Used to treat infections caused by penicillinase-producing staphylococci, including pneumococci, group A beta-hemolytic streptococci, and penicillin G-sensitive and penicillin G-resistant staphylococci. |
| Pharmacology |
Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin is for use against staphylococci that produce beta-lactamase. |
| Toxicity |
Oral LD50 in rat and mouse is 5000 mg/kg. Intravenous LD50 in rat is 1660 mg/kg. Symptoms of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, and swelling of face, lips, tongue, or throat. |
| Affected Organisms |
| • |
Enteric bacteria and other eubacteria |
|
| Absorption |
Well absorbed from the gastrointestinal tract. |
| Protein Binding |
95% |
| External Links |
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