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Diphenylpyraline

产品号 DB01146 公司名称 DrugBank
CAS号 147-20-6 公司网站 http://www.ualberta.ca/
分子式 C19H23NO 电 话 (780) 492-3111
分子量 281.39202 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 1017

产品价格信息

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产品别名

标题
Diphenylpyraline
IUPAC标准名
4-(diphenylmethoxy)-1-methylpiperidine
IUPAC传统名
diphenylpyraline
商标名
Mepiben
Lyssipoll
Dafen
Allergen
Belfene
Dayfen
Diafen
Hispril
Histryl
Histyn
Hystryl
Neargal
别名
Diphenylpyrilene
Diphenylpyralamine
Diphenylpyraline Hydrochloride

产品登记号

PubChem CID 3103
CAS号 147-20-6
PubChem SID 46504936

产品性质

疏水性(logP) 3.7

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description Diphenylpyraline is an antihistamine. Antihistamines used in the treatment of allergy act by competing with histamine for H 1-receptor sites on effector cells. Antihistamines prevent, but do not reverse, responses mediated by histamine alone. Antihistamines antagonize, in varying degrees, most of the pharmacological effects of histamine, including urticaria and pruritus.
Indication For use in the treatment of allergic rhinitis, hay fever, and allergic skin disorders.
Pharmacology Diphenylpyraline is an antihistamine that prevents, but does not reverse, responses mediated by histamine alone. Diphenylpyraline antagonizes most of the pharmacological effects of histamine, including urticaria and pruritus. Also, diphenylpyraline may exhibit anticholinergic actions (as do most of the antihistamines) and may thus provide a drying effect on the nasal mucosa.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic
Absorption Well absorbed after oral administration.
Protein Binding > 99% in human serum albumin
References
Lapa GB, Mathews TA, Harp J, Budygin EA, Jones SR: Diphenylpyraline, a histamine H1 receptor antagonist, has psychostimulant properties. Eur J Pharmacol. 2005 Jan 4;506(3):237-40. Epub 2004 Dec 8. [Pubmed]
Ohno T, Kobayashi S, Hayashi M, Sakurai M, Kanazawa I: Diphenylpyraline-responsive parkinsonism in cerebrotendinous xanthomatosis: long-term follow up of three patients. J Neurol Sci. 2001 Jan 1;182(2):95-7. [Pubmed]
Puhakka H, Rantanen T, Virolainen E: Diphenylpyraline (Lergobine) in the treatment of patients suffering from allergic and vasomotor rhinitis. J Int Med Res. 1977;5(1):37-41. [Pubmed]
External Links
Wikipedia

参考文献

  • Lapa GB, Mathews TA, Harp J, Budygin EA, Jones SR: Diphenylpyraline, a histamine H1 receptor antagonist, has psychostimulant properties. Eur J Pharmacol. 2005 Jan 4;506(3):237-40. Epub 2004 Dec 8. Pubmed
  • Ohno T, Kobayashi S, Hayashi M, Sakurai M, Kanazawa I: Diphenylpyraline-responsive parkinsonism in cerebrotendinous xanthomatosis: long-term follow up of three patients. J Neurol Sci. 2001 Jan 1;182(2):95-7. Pubmed
  • Puhakka H, Rantanen T, Virolainen E: Diphenylpyraline (Lergobine) in the treatment of patients suffering from allergic and vasomotor rhinitis. J Int Med Res. 1977;5(1):37-41. Pubmed