Dichlorphenamide

• 产品号: DB01144
• CAS号: 120-97-8
• 分子式: C6H6Cl2N2O4S2
• 分子量: 305.15884

产品别名

• 标题: Dichlorphenamide
• IUPAC标准名: 4,5-dichlorobenzene-1,3-disulfonamide
• IUPAC传统名: dichlorphenamide
• 商标名: Daranide; Antidrasi; Dasanide; Glaucol; Oratrol
• 别名: Diclofenamida [INN-Spanish]; Dichlorophenamide; Diclofenamide; Diclofenamidum [INN-Latin]; Dichlorphenamid; Dichlofenamide

产品登记号

• CAS号: 120-97-8
• PubChem SID: 46505039
• PubChem CID: 3038

产品性质

• 疏水性(logP): 0.2

产品详细信息

详细说明 (English)

• Drug Groups: approved
• Description: A carbonic anhydrase inhibitor that is used in the treatment of glaucoma. [PubChem]
• Indication: For adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure
• Pharmacology: Dichlorphenamide is an oral carbonic anhydrase inhibitor indicated for adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure. Carbonic anhydrase inhibitors reduce intraocular pressure by partially suppressing the secretion of aqueous humor (inflow).
• Affected Organisms: Humans and other mammals
• Protein Binding: 55%
• References: Tawil R, McDermott MP, Brown R Jr, Shapiro BC, Ptacek LJ, McManis PG, Dalakas MC, Spector SA, Mendell JR, Hahn AF, Griggs RC: Randomized trials of dichlorphenamide in the periodic paralyses. Working Group on Periodic Paralysis. Ann Neurol. 2000 Jan;47(1):46-53. [Pubmed] ; Okada S, Izumi W, Murai M, Komatsu H, Ishimitsu S: [Diclofenamide Reference Standard (Control 891) of National Institute of Hygienic Sciences] Eisei Shikenjo Hokoku. 1991;(109):148-50. [Pubmed]
• External Links: Wikipedia; RxList; Drugs.com

参考文献

• Tawil R, McDermott MP, Brown R Jr, Shapiro BC, Ptacek LJ, McManis PG, Dalakas MC, Spector SA, Mendell JR, Hahn AF, Griggs RC: Randomized trials of dichlorphenamide in the periodic paralyses. Working Group on Periodic Paralysis. Ann Neurol. 2000 Jan;47(1):46-53. Pubmed
• Okada S, Izumi W, Murai M, Komatsu H, Ishimitsu S: [Diclofenamide Reference Standard (Control 891) of National Institute of Hygienic Sciences] Eisei Shikenjo Hokoku. 1991;(109):148-50. Pubmed