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L-Lysine

产品号 DB00123 公司名称 DrugBank
CAS号 56-87-1 公司网站 http://www.ualberta.ca/
分子式 C6H14N2O2 电 话 (780) 492-3111
分子量 146.18756 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 10

产品价格信息

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产品别名

标题
L-Lysine
IUPAC标准名
(2S)-2,6-diaminohexanoic acid
IUPAC传统名
L-lysine
商标名
Enisyl
别名
2,6-diaminohexanoic acid
L-lys
LYS
lysine
lysine acid

产品登记号

CAS号 56-87-1
PubChem CID 5962
PubChem SID 46504770

产品性质

疏水性(logP) -2.9
溶解度 appreciable

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved; nutraceutical
Description L-Lysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG.

L-Lysine is a base, as are arginine and histidine. The ε-amino group often participates in hydrogen bonding and as a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.
Indication Supplemental L-lysine has putative anti-herpes simplex virus activity. There is preliminary research suggesting that it may have some anti-osteoporotic activity.
Pharmacology Insures the adequate absorption of calcium; helps form collagen ( which makes up bone cartilage & connective tissues); aids in the production of antibodies, hormones & enzymes. Recent studies have shown that Lysine may be effective against herpes by improving the balance of nutrients that reduce viral growth. A deficiency may result in tiredness, inability to concentrate, irritability, bloodshot eyes, retarded growth, hair loss, anemia & reproductive problems.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic
Absorption Absorbed from the lumen of the small intestine into the enterocytes by an active transport process
References
Griffith RS, Norins AL, Kagan C: A multicentered study of lysine therapy in Herpes simplex infection. Dermatologica. 1978;156(5):257-67. [Pubmed]
External Links
Wikipedia
PDRhealth

参考文献

  • Griffith RS, Norins AL, Kagan C: A multicentered study of lysine therapy in Herpes simplex infection. Dermatologica. 1978;156(5):257-67. Pubmed