[bis(benzyloxy)phosphanyl]bis(propan-2-yl)amine

• ChemBase编号: 90442
• 分子式: C20H28NO2P
• 平均质量: 345.415581
• 单一同位素质量: 345.18576577
• SMILES: P(N(C(C)C)C(C)C)(OCc1ccccc1)OCc1ccccc1
• Canonical SMILES: CC(N(P(OCc1ccccc1)OCc1ccccc1)C(C)C)C
• InChI: InChI=1S/C20H28NO2P/c1-17(2)21(18(3)4)24(22-15-19-11-7-5-8-12-19)23-16-20-13-9-6-10-14-20/h5-14,17-18H,15-16H2,1-4H3
• InChIKey: ANPWLBTUUNFQIO-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: [bis(benzyloxy)phosphanyl]bis(propan-2-yl)amine
• IUPAC传统名: [bis(benzyloxy)phosphanyl]diisopropylamine
• 别名: 二苄基 N,N-二异丙基亚磷酰胺; 二苄基二异丙基胺基膦; Dibenzyl N,N-diisopropylphosphoramidite, tech 90%; N,N-Bis(1-methylethyl)phosphoramidous Acid Bis(phenylmethyl) Ester; Bis(benzyloxy)(diisopropylamino)phosphine; Dibenzyl Diisopropylphosphoramidite; Dibenzyl N,N-Diisopropylphosphoramidite, Technical grade; Dibenzyl N,N-diisopropylphosphoramidite; Dibenzyl diisopropylphosphoramidite

登记号

• CAS号: 108549-23-1
• MDL号: MFCD00191988
• Beilstein号: 3616864
• PubChem SID: 24866075; 162077250
• PubChem CID: 196621

理论计算性质

• LogD (pH = 5.5): 2.6437905
• LogD (pH = 7.4): 4.265464
• Log P: 5.5668
• 摩尔折射率: 102.3832 cm^3
• 极化性: 40.297047 Å^3
• 极化表面积: 21.7 Å^2
• 可自由旋转的化学键: 9
• 里宾斯基五规则: false
• 质子受体: 3
• 质子供体: 0

分子性质

理化性质

• 溶解度: Chloroform
• 外观: Clear Colourless Liquid
• 沸点: 130 °C/0.55 mmHg(lit.); 130°C/0.55mm
• 闪点: 156.2 °F; 69 °C; 69°C(156°F)
• 密度: 1.028 g/mL at 25 °C(lit.); 1.030
• 折射率: n20/D 1.535(lit.)

安全信息

• 保存条件: Refrigerator, Under Inert Atmosphere
• 保存注意事项: Irritant; Moisture Sensitive
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 德国WGK号: 3
• 危险公开号: 36/37/38
• 安全公开号: 26-36; 26-37
• TSCA收录: 否
• GHS危险品标识: GHS07
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335; H315-H319-H335-H227
• GHS警示性声明: P210-P305+P351+P338-P302+P352-P321-P405-P501A; P261-P305 + P351 + P338
• 个人保护装置: Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• 保存温度: 2-8°C

产品相关信息

• 纯度: ≥97.0% (CHN); 90%; 95%
• 级别: purum; technical grade
• 线性分子式: [(CH3)2CH]2NP(OCH2C6H5)2

详细说明

Sigma Aldrich - 416436

Application
核苷酸偶联/合成试剂。1,2
包装
5, 25 mL in glass bottle

Sigma Aldrich - 33735

Other Notes
用于由肌醇合成磷酸肌醇的苄酯的亚磷酸化剂1,2

Toronto Research Chemicals - D417500

A versatile phosphitylating agent.

参考文献

• Perich, J.W., et al.: Synthesis, 142 (1988)
• Phosphitylating agent which reacts with an alcohol under mild conditions. Subsequent oxidation, e.g. with hydrogen peroxide, followed by hydrogenolysis of the benzyl groups, affords the alkyl phosphate: Tetrahedron Lett., 29, 979 (1988).